ALX4 and FOXA3

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		ALX4	FOXA3
Name		ALX homeobox 4	forkhead box A3
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Actin Cytoskeleton
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Limb Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Digestive Tract Development Neuron Development Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development	Intracellular Glucose Homeostasis Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Spermatogenesis Cellular Response To Starvation Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Homeostasis
Pathways		None	Regulation of gene expression in beta cells
Diseases		Enlarged parietal foramina/cranium bifidum Frontonasal dysplasia	None
GWAS		Blood pressure measurement (high sodium intervention) ( 24165912 ) Brain morphology (MOSTest) ( 32665545 ) Cadmium levels ( 26025379 ) Excessive hairiness ( 29895819 ) ghrelin levels ( 33852427 ) Gout ( 22179738 ) Male-pattern baldness ( 27182965 29146897 ) Monobrow ( 27182965 ) Response to antidepressants in depression ( 29998114 ) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355 )	Asthma ( 31959851 32296059 ) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143 ) Coronary artery disease ( 29212778 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Sum eosinophil basophil counts ( 27863252 )
Interacting Genes		14 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 IQUB LEF1 PARVG SOX10 SOX2	5 interacting genes: ALX4 HMGB1 PPARA TLE1 TLE2
Entrez ID		60529	3171
HPRD ID		05661	03802
Ensembl ID		ENSG00000052850	ENSG00000170608
Uniprot IDs		Q9H161	P55318
PDB IDs		2M0C 8OSB	1VTN
GO Terms Enriched among Interactors		Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Regionalization DNA Binding Anterior/posterior Pattern Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Pattern Specification Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Anatomical Structure Morphogenesis Regulation Of RNA Metabolic Process Gland Development Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Skeletal System Morphogenesis Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Regulation Of Macromolecule Biosynthetic Process Embryonic Organ Morphogenesis Glossopharyngeal Nerve Morphogenesis Regulation Of Primary Metabolic Process Developmental Process Animal Organ Development Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Radial Glial Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Cranial Nerve Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Glial Cell Differentiation Nucleus System Development Morphogenesis Of An Epithelium RNA Polymerase II Transcription Regulator Complex	Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Programmed Cell Death DNA-binding Transcription Factor Binding Regulation Of RNA Metabolic Process Transcription Regulator Complex Positive Regulation Of Glucose Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Chemotaxis Positive Regulation Of Binding Regulation Of Carbohydrate Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Animal Organ Development Negative Regulation Of RNA Biosynthetic Process Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Activity Negative Regulation Of Signal Transduction Positive Regulation Of Transformation Of Host Cell By Virus Animal Organ Morphogenesis Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Endothelial Cell Migration Developmental Process Negative Regulation Of Apoptotic Cell Clearance Anatomical Structure Morphogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Macromolecule Metabolic Process C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Positive Regulation Of Mismatch Repair Regulation Of Signal Transduction Positive Regulation Of Chemotaxis Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Epidermis Development