ELAC2 and CUX1

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ELAC2	CUX1
Name		elaC ribonuclease Z 2	cut like homeobox 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Nucleoid	Golgi Membrane Chromatin Nucleus Nucleoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity TRNA-specific Ribonuclease Activity Hydrolase Activity 3'-tRNA Processing Endoribonuclease Activity Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	TRNA Processing TRNA Decay TRNA 3'-end Processing Mitochondrial TRNA Processing Mitochondrial TRNA 3'-end Processing	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intra-Golgi Vesicle-mediated Transport Positive Regulation Of Dendrite Morphogenesis
Pathways		tRNA processing in the nucleus tRNA processing in the mitochondrion rRNA processing in the mitochondrion tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
GWAS		Squamous cell lung carcinoma ( 28604730 )	Attention deficit hyperactivity disorder symptom score ( 27663945 ) Basal cell carcinoma ( 27539887 33549134 31174203 ) Breast cancer ( 29059683 ) Cerebellum cortex volume ( 31530798 ) Chronotype ( 30696823 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) HDL cholesterol levels ( 32203549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Intelligence (MTAG) ( 29326435 ) Keratinocyte cancer (MTAG) ( 31174203 ) Mean platelet volume ( 32888494 27863252 ) Morning person ( 30696823 ) Platelet distribution width ( 32888494 27863252 ) Plateletcrit ( 32888494 27863252 ) Response to antidepressants ( 22584459 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		10 interacting genes: ASCC2 CTBP1 CTBP2 CUX1 GOLM1 NDUFA7 RING1 RNF10 SMAD2 SUMO2	23 interacting genes: BIN1 CA12 CCNA1 CCNB1 CDC25A CDK1 CDK7 CHAF1B CREBBP CTSL CYTH2 EHMT2 ELAC2 GOLGA5 HMGB1 KAT2B MAX RB1 RECQL5 SATB1 SDC3 SUMO2 TLE4
Entrez ID		60528	1523
HPRD ID		05641	00295
Ensembl ID		ENSG00000006744	ENSG00000257923
Uniprot IDs		A0A0S2Z5M8 Q9BQ52	P39880 Q13948 Q3LIA3
PDB IDs		8CBL 8RR1 8RR3 8RR4 8Z0P 8Z1F 8Z1G 9EY0 9EY1 9EY2	8WQE 8WQF 8WQI
GO Terms Enriched among Interactors		Ribosome-associated Ubiquitin-dependent Protein Catabolic Process White Fat Cell Differentiation Viral Genome Replication Regulation Of DNA-templated Transcription NAD Binding DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of RNA Metabolic Process Transcription Corepressor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transcription Repressor Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Homomeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Ubiquitin Protein Ligase Activity Cytosolic Ribosome RQC-trigger Complex GABA-ergic Synapse Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Ligase Complex	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle DNA-binding Transcription Factor Binding Nucleoplasm Mitotic Cell Cycle Phase Transition Cyclin B1-CDK1 Complex Cell Division Chromatin Remodeling Mitotic DNA-templated DNA Replication Cyclin A1-CDK1 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic DNA Replication N-terminal Peptidyl-lysine Acetylation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Chromatin Organization Positive Regulation Of Chromosome Segregation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Sister Chromatid Segregation Positive Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Nuclear DNA Replication Regulation Of Chromosome Segregation Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle DNA Repair Cell Cycle G2/M Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Ventricular Cardiac Muscle Cell Development