SAV1 and STK4

Number of citations: 0 (PubMedID 16930133)
Data Source: HPRD (in vivo, in vitro)

		SAV1	STK4
Name		salvador family WW domain containing protein 1	serine/threonine kinase 4
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Transcription Regulator Activator Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Hair Follicle Development Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Keratinocyte Differentiation Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Keratinocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Stem Cell Population Maintenance	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Anatomical Structure Morphogenesis Peptidyl-serine Phosphorylation Keratinocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Pathways		Signaling by Hippo	Signaling by Hippo
GWAS		Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Dupuytren's disease ( 28886342 ) Heel bone mineral density ( 30598549 ) Lupus nephritis in systemic lupus erythematosus ( 24925725 ) Mean platelet volume ( 27863252 32888494 ) Periodontal disease-related phenotype (Socransky) ( 24347629 ) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Refractive error ( 32231278 )	Bipolar disorder ( 31043756 33263727 34002096 ) Mean platelet volume ( 32888494 ) Platelet count ( 32888494 )
Interacting Genes		4 interacting genes: EP300 NEDD4 STK3 STK4	25 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX DDIT4L H2BC21 HSPA4 IL2RG KEAP1 LATS1 MBP NEDD4 OGT PICK1 RASSF1 RASSF5 RNF31 RNF6 SAV1 SGMS1 SIRT1 THAP12 TP53 TRIM69
Entrez ID		60485	6789
HPRD ID		06229	05395
Ensembl ID		ENSG00000151748	ENSG00000101109
Uniprot IDs		B3KTQ1 Q9H4B6	A0A087WVN8 Q13043
PDB IDs		6AO5	2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT 8A5J 8PAV 8PAW
GO Terms Enriched among Interactors		Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Canonical Wnt Signaling Pathway Neural Tube Formation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Organelle Hepatocyte Apoptotic Process Hemopoiesis Positive Regulation Of Hippo Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Embryonic Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Embryonic Epithelial Tube Formation Hippo Signaling Protein Stabilization Wnt Signaling Pathway Epithelial Tube Formation Negative Regulation Of Organ Growth Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction System Development Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Regulation Of Hippo Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Epithelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organ Growth Positive Regulation Of Intracellular Signal Transduction Developmental Growth Regulation Of Protein Stability Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Fat Cell Differentiation Protein Serine/threonine Kinase Activator Activity Cellular Response To UV Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Protein Transport Formation Of Structure Involved In A Symbiotic Process Protein Tetramerization Positive Regulation Of Hepatocyte Apoptotic Process	Apoptotic Process Programmed Cell Death Regulation Of Autophagy Cell Death Intracellular Signal Transduction Regulation Of Macroautophagy Response To Stress Regulation Of Proteolysis Identical Protein Binding Regulation Of Protein Metabolic Process Keratinocyte Differentiation Positive Regulation Of Protein Metabolic Process Response To UV Immune System Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Hippo Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Regulation Of Glucose Metabolic Process Epidermal Cell Differentiation Glial Cell Apoptotic Process Regulation Of Programmed Necrotic Cell Death PML Body Keratin Filament Binding Signal Transduction Transcription Regulator Inhibitor Activity Positive Regulation Of Metabolic Process Regulation Of Endodeoxyribonuclease Activity Nucleus Regulation Of Post-translational Protein Modification T Cell Differentiation In Thymus Stress-induced Premature Senescence Protein Ubiquitination Post-translational Protein Modification Cytoplasm Regulation Of Hippo Signaling Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Leukocyte Apoptotic Process Cellular Response To Glucose Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Transcription By Glucose Cellular Response To Decreased Oxygen Levels Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Signaling