RIT2 and RLF

Number of citations: 0 (PubMedID 10545207)
Data Source: BioGRID (pull down), HPRD (in vitro)

		RIT2	RLF
Name		Ras like without CAAX 2	RLF zinc finger
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree	Nucleus
	Molecular Function	Nucleotide Binding Chromatin Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding Semaphorin Receptor Binding Identical Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Heterochromatin Formation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Signalling to p38 via RIT and RIN	None
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525 ) Acute lymphoblastic leukemia (childhood) ( 23007406 ) Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Age at first sexual intercourse ( 34211149 ) Alcohol consumption (drinks per week) ( 30679032 ) Apolipoprotein A1 levels ( 32203549 ) Autism spectrum disorder ( 26314684 ) Body mass index ( 28552196 28892062 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive performance ( 19734545 ) Coronary artery calcification ( 23870195 ) HDL cholesterol levels ( 32203549 ) Metabolite levels ( 23823483 ) Number of sexual partners ( 30643258 ) Parkinson's disease ( 21738487 22451204 32310270 32201043 25064009 27182965 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Periodontitis (PAL4Q3) ( 24024966 ) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 ) Waist circumference ( 25673412 ) Weight ( 28552196 )	High density lipoprotein cholesterol levels ( 30498476 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 )
Interacting Genes		13 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RGL3 RLF SOS1 SRPK2	7 interacting genes: CLK1 FBXL17 GCH1 PRPF40A RIT1 RIT2 TRIM14
Entrez ID		6014	6018
HPRD ID		15253	01614
Ensembl ID		ENSG00000152214	ENSG00000117000
Uniprot IDs		Q99578	Q13129
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Ras Protein Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Signal Transduction GTPase Complex Regulation Of Long-term Neuronal Synaptic Plasticity Small GTPase-mediated Signal Transduction Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Glial Cell Development Positive Regulation Of Neuron Apoptotic Process Guanyl-nucleotide Exchange Factor Activity Regulation Of Neuron Apoptotic Process Schwann Cell Development Positive Regulation Of Gene Expression Plasma Membrane Endocytosis Cell Development Cell Junction Organization Modulation Of Chemical Synaptic Transmission Positive Chemotaxis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Projection Assembly Proprioception Involved In Equilibrioception Synapse Organization Import Into Cell Cell Junction Assembly Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Projection Organization Regulation Of MiRNA Metabolic Process Endosome To Plasma Membrane Transport Vesicle Chemotaxis Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Type II Interferon Production Cell Surface Receptor Signaling Pathway Regulation Of Calcium-mediated Signaling Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import	GTPase Activity GTP Cyclohydrolase I Activity GTP Binding GDP Binding G Protein Activity Ras Protein Signal Transduction