RIT2 and POU4F1

Number of citations: 0 (PubMedID 12934100)
Data Source: HPRD (two hybrid, in vitro)

		RIT2	POU4F1
Name		Ras like without CAAX 2	POU class 4 homeobox 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree	Chromatin Nucleus Nucleoplasm Cytoplasm Neuron Projection RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Chromatin Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding Semaphorin Receptor Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Single-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding GTPase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Suckling Behavior Ventricular Compact Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Synapse Assembly Mesoderm Development Heart Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration In Hindbrain Trigeminal Nerve Development Central Nervous System Neuron Differentiation Habenula Development Neuron Differentiation Neuron Projection Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Sensory System Development Peripheral Nervous System Neuron Differentiation Peripheral Nervous System Neuron Development Regulation Of Neurogenesis Regulation Of DNA-binding Transcription Factor Activity Proprioception Involved In Equilibrioception Neuron Apoptotic Process Regulation Of Cell Cycle Innervation Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Signalling to p38 via RIT and RIN	Regulation of TP53 Activity through Association with Co-factors
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525 ) Acute lymphoblastic leukemia (childhood) ( 23007406 ) Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Age at first sexual intercourse ( 34211149 ) Alcohol consumption (drinks per week) ( 30679032 ) Apolipoprotein A1 levels ( 32203549 ) Autism spectrum disorder ( 26314684 ) Body mass index ( 28552196 28892062 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive performance ( 19734545 ) Coronary artery calcification ( 23870195 ) HDL cholesterol levels ( 32203549 ) Metabolite levels ( 23823483 ) Number of sexual partners ( 30643258 ) Parkinson's disease ( 21738487 22451204 32310270 32201043 25064009 27182965 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Periodontitis (PAL4Q3) ( 24024966 ) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 ) Waist circumference ( 25673412 ) Weight ( 28552196 )	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353 ) Total ventricular volume (Alzheimer's disease interaction) ( 21116278 )
Interacting Genes		13 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RGL3 RLF SOS1 SRPK2	4 interacting genes: ESR1 EWSR1 MAPRE3 RIT2
Entrez ID		6014	5457
HPRD ID		15253	03379
Ensembl ID		ENSG00000152214	ENSG00000152192
Uniprot IDs		Q99578	Q01851
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Ras Protein Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Signal Transduction GTPase Complex Regulation Of Long-term Neuronal Synaptic Plasticity Small GTPase-mediated Signal Transduction Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Glial Cell Development Positive Regulation Of Neuron Apoptotic Process Guanyl-nucleotide Exchange Factor Activity Regulation Of Neuron Apoptotic Process Schwann Cell Development Positive Regulation Of Gene Expression Plasma Membrane Endocytosis Cell Development Cell Junction Organization Modulation Of Chemical Synaptic Transmission Positive Chemotaxis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Projection Assembly Proprioception Involved In Equilibrioception Synapse Organization Import Into Cell Cell Junction Assembly Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Projection Organization Regulation Of MiRNA Metabolic Process Endosome To Plasma Membrane Transport Vesicle Chemotaxis Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Type II Interferon Production Cell Surface Receptor Signaling Pathway Regulation Of Calcium-mediated Signaling Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import	Calmodulin Binding Nuclear Estrogen Receptor Activity Regulation Of Branching Involved In Prostate Gland Morphogenesis TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Mammary Gland Branching Involved In Pregnancy Regulation Of Gene Expression Antral Ovarian Follicle Growth Regulation Of Nitric-oxide Synthase Activity Identical Protein Binding Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Neuron Projection Development Dendritic Tree Mitotic Spindle Astral Microtubule End Microtubule End Nitric-oxide Synthase Regulator Activity Neuron To Neuron Synapse Branching Involved In Prostate Gland Morphogenesis Regulation Of Macromolecule Metabolic Process Estrogen Response Element Binding Prostate Gland Growth Regulation Of Canonical NF-kappaB Signal Transduction Vagina Development Regulation Of Cdc42 Protein Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Cellular Response To Estrogen Stimulus Branch Elongation Of An Epithelium Axis Elongation Mammary Gland Alveolus Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Mammary Gland Epithelial Cell Proliferation Regulation Of RNA Biosynthetic Process Female Genitalia Development Regulation Of Metabolic Process Golgi Apparatus Regulation Of Oxidoreductase Activity Positive Regulation Of Cell Projection Organization Protein Localization To Microtubule Behavioral Response To Cocaine Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Prostate Gland Epithelium Morphogenesis Estrogen Receptor Signaling Pathway