RIT2 and RGL1

Number of citations: 0 (PubMedID 10545207)
Data Source: HPRD (in vitro)

		RIT2	RGL1
Name		Ras like without CAAX 2	ral guanine nucleotide dissociation stimulator like 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree	Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Chromatin Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding Semaphorin Receptor Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	MAPK Cascade Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways		Signalling to p38 via RIT and RIN	PPARA activates gene expression RAF/MAP kinase cascade
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525 ) Acute lymphoblastic leukemia (childhood) ( 23007406 ) Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Age at first sexual intercourse ( 34211149 ) Alcohol consumption (drinks per week) ( 30679032 ) Apolipoprotein A1 levels ( 32203549 ) Autism spectrum disorder ( 26314684 ) Body mass index ( 28552196 28892062 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive performance ( 19734545 ) Coronary artery calcification ( 23870195 ) HDL cholesterol levels ( 32203549 ) Metabolite levels ( 23823483 ) Number of sexual partners ( 30643258 ) Parkinson's disease ( 21738487 22451204 32310270 32201043 25064009 27182965 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Periodontitis (PAL4Q3) ( 24024966 ) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 ) Waist circumference ( 25673412 ) Weight ( 28552196 )	Antipsychotic drug-induced QTc interval change in schizophrenia ( 29064910 ) Aspartate aminotransferase levels ( 33547301 33339817 29403010 ) Attention deficit hyperactivity disorder and conduct disorder ( 18951430 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) Immature fraction of reticulocytes ( 32888494 ) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954 ) Response to antidepressants ( 20360315 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Retinal detachment or retinal break ( 31816047 )
Interacting Genes		13 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RGL3 RLF SOS1 SRPK2	5 interacting genes: APP FOXP1 HRAS RIT1 RIT2
Entrez ID		6014	23179
HPRD ID		15253	12032
Ensembl ID		ENSG00000152214	ENSG00000143344
Uniprot IDs		Q99578	B7Z2W5 B7Z915 B7ZB61 Q9NZL6
PDB IDs		Not available	7SCW 7SCX
GO Terms Enriched among Interactors		Ras Protein Signal Transduction Intracellular Signaling Cassette Intracellular Signal Transduction Signal Transduction GTPase Complex Regulation Of Long-term Neuronal Synaptic Plasticity Small GTPase-mediated Signal Transduction Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Glial Cell Development Positive Regulation Of Neuron Apoptotic Process Guanyl-nucleotide Exchange Factor Activity Regulation Of Neuron Apoptotic Process Schwann Cell Development Positive Regulation Of Gene Expression Plasma Membrane Endocytosis Cell Development Cell Junction Organization Modulation Of Chemical Synaptic Transmission Positive Chemotaxis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Projection Assembly Proprioception Involved In Equilibrioception Synapse Organization Import Into Cell Cell Junction Assembly Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Cell Projection Organization Regulation Of MiRNA Metabolic Process Endosome To Plasma Membrane Transport Vesicle Chemotaxis Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Type II Interferon Production Cell Surface Receptor Signaling Pathway Regulation Of Calcium-mediated Signaling Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import	GDP Binding G Protein Activity Ras Protein Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Regulation Of Neuronal Synaptic Plasticity Myeloid Cell Development Macrophage Activation Glial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Cell Body Positive Regulation Of MAPK Cascade Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of JNK Cascade Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Type II Interferon Production Regulation Of Calcium-mediated Signaling Positive Regulation Of Signal Transduction Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cell Motility Acetylcholine Receptor Activator Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Intracellular Signal Transduction Regulation Of Cell Projection Organization Regulation Of Interleukin-1 Production Positive Regulation Of Cell Communication Regulation Of Type II Interferon Production Positive Regulation Of Signaling Lipoprotein Particle Myeloid Leukocyte Activation Positive Regulation Of Locomotion Positive Regulation Of Protein Import Regulation Of MAPK Cascade GTPase Complex Positive Regulation Of Interleukin-21 Production PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Cell Activation Involved In Immune Response Endosome To Plasma Membrane Transport Vesicle