GRK1 and RHO

Number of citations: 25 (PubMedID 11910029)
Data Source: HPRD (in vitro, in vivo)

		GRK1	RHO
Name		G protein-coupled receptor kinase 1	rhodopsin
Structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Membrane Cell Projection Photoreceptor Disc Membrane	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Cell-cell Junction Membrane Golgi-associated Vesicle Membrane Photoreceptor Outer Segment Membrane Cell Projection Ciliary Membrane Photoreceptor Inner Segment Membrane Sperm Midpiece Photoreceptor Disc Membrane Rod Photoreceptor Outer Segment Sperm Head Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity ATP Binding Kinase Activity Transferase Activity Rhodopsin Kinase Activity	G Protein-coupled Receptor Activity 11-cis Retinal Binding Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity Metal Ion Binding
	Biological Process	Signal Transduction Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Light Stimulus Regulation Of Signal Transduction G Protein-coupled Opsin Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway Protein Autophosphorylation	Microtubule Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Phototransduction, Visible Light Response To Light Stimulus Detection Of Light Stimulus Response To Light Intensity Gene Expression Absorption Of Visible Light G Protein-coupled Opsin Signaling Pathway Thermotaxis Photoreceptor Cell Maintenance Sensory Perception Of Light Stimulus Detection Of Temperature Stimulus Involved In Thermoception Retina Development In Camera-type Eye Cellular Response To Light Stimulus Podosome Assembly Rod Bipolar Cell Differentiation
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade	The canonical retinoid cycle in rods (twilight vision) Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Opsins VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs		None	Halothane N-Acetylmethionine 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine B-nonylglucoside Phosphonothreonine B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Dodecyldimethylamine N-oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane e Dexfosfoserine
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO)	Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		No GWAS studies recorded	Diisocyanate-induced asthma ( 25918132 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		9 interacting genes: ADRB2 CALM1 CAV1 PDE6D RCVRN RHO SNCA SNCB SNCG	12 interacting genes: ARR3 ARRB2 CD79A DERL1 GNGT1 GRK1 GRK2 GRK5 GRK6 PPP2CA PRKCA SAG
Entrez ID		6011	6010
HPRD ID		01585	01584
Ensembl ID		ENSG00000185974	ENSG00000163914
Uniprot IDs		Q15835	P08100
PDB IDs		5AFP	4ZWJ 5DGY 5W0P 6CMO
GO Terms Enriched among Interactors		Presynaptic Endocytosis Cuprous Ion Binding Endocytosis Vesicle-mediated Transport In Synapse Import Into Cell Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Synaptic Vesicle Endocytosis Axon Terminus Regulation Of Calcium Ion Transport Vesicle-mediated Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Cell Communication By Electrical Coupling Establishment Of Localization In Cell Regulation Of Transport Inclusion Body Regulation Of Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Regulation Of Dopamine Secretion Regulation Of Muscle Contraction Receptor-mediated Endocytosis Modulation Of Chemical Synaptic Transmission Regulation Of Cardiac Muscle Cell Action Potential Visual Perception Dopamine Metabolic Process Sensory Perception Of Light Stimulus Cilium Calcium Ion Binding Regulation Of Catecholamine Secretion Phototransduction Cell Projection Regulation Of Muscle System Process Protein Sequestering Activity Catecholamine Metabolic Process Detection Of Stimulus Synapse Organization Sperm Midpiece Regulation Of Monoatomic Cation Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential System Process Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Action Potential Inward Rectifier Potassium Channel Inhibitor Activity Positive Regulation Of Calcium Ion Transmembrane Transport Photoreceptor Inner Segment	G Protein-coupled Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Signal Transduction G Protein-coupled Receptor Internalization Photoreceptor Outer Segment Receptor Internalization G Protein-coupled Receptor Binding Opsin Binding Phototransduction Protein Serine/threonine Kinase Activity Receptor-mediated Endocytosis G Protein-coupled Opsin Signaling Pathway G Protein-coupled Receptor Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Photoreceptor Inner Segment Detection Of Light Stimulus Negative Adaptation Of Signaling Pathway Tachykinin Receptor Signaling Pathway Protein Kinase Activity Kinase Activity Detection Of Abiotic Stimulus Photoreceptor Disc Membrane Endocytosis Nervous System Process System Process Sensory Perception Membrane Phosphoprotein Binding Positive Regulation Of Cardiac Muscle Hypertrophy Postsynaptic Signal Transduction Negative Regulation Of Relaxation Of Smooth Muscle Import Into Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Detection Of Stimulus RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Edg-2 Lysophosphatidic Acid Receptor Binding Angiotensin Receptor Binding Response To Light Stimulus RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Derlin-1-VIMP Complex Protein Phosphorylation