GRK1 and RCVRN

Number of citations: 0 (PubMedID 9753452)
Data Source: HPRD (in vitro)

		GRK1	RCVRN
Name		G protein-coupled receptor kinase 1	recoverin
Structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Membrane Cell Projection Photoreceptor Disc Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Membrane Dendrite Cell Projection Perikaryon
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity ATP Binding Kinase Activity Transferase Activity Rhodopsin Kinase Activity	Calcium Ion Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding
	Biological Process	Signal Transduction Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Light Stimulus Regulation Of Signal Transduction G Protein-coupled Opsin Signaling Pathway Regulation Of Opsin-mediated Signaling Pathway Protein Autophosphorylation	Signal Transduction Visual Perception Phototransduction Regulation Of Signal Transduction Regulation Of Calcium Ion Transport
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade	Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade
Drugs		None	Myristic acid
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO)	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		9 interacting genes: ADRB2 CALM1 CAV1 PDE6D RCVRN RHO SNCA SNCB SNCG	11 interacting genes: CAV1 GIT2 GRK1 GRK2 GRK5 GRK6 IL15RA PQBP1 SMAD3 TGFBR2 TOP1
Entrez ID		6011	5957
HPRD ID		01585	01558
Ensembl ID		ENSG00000185974	ENSG00000109047
Uniprot IDs		Q15835	P35243
PDB IDs		5AFP	2D8N
GO Terms Enriched among Interactors		Presynaptic Endocytosis Cuprous Ion Binding Endocytosis Vesicle-mediated Transport In Synapse Import Into Cell Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Synaptic Vesicle Endocytosis Axon Terminus Regulation Of Calcium Ion Transport Vesicle-mediated Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Cell Communication By Electrical Coupling Establishment Of Localization In Cell Regulation Of Transport Inclusion Body Regulation Of Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Regulation Of Dopamine Secretion Regulation Of Muscle Contraction Receptor-mediated Endocytosis Modulation Of Chemical Synaptic Transmission Regulation Of Cardiac Muscle Cell Action Potential Visual Perception Dopamine Metabolic Process Sensory Perception Of Light Stimulus Cilium Calcium Ion Binding Regulation Of Catecholamine Secretion Phototransduction Cell Projection Regulation Of Muscle System Process Protein Sequestering Activity Catecholamine Metabolic Process Detection Of Stimulus Synapse Organization Sperm Midpiece Regulation Of Monoatomic Cation Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential System Process Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Action Potential Inward Rectifier Potassium Channel Inhibitor Activity Positive Regulation Of Calcium Ion Transmembrane Transport Photoreceptor Inner Segment	G Protein-coupled Receptor Kinase Activity Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Gastrulation Regulation Of The Force Of Heart Contraction By Chemical Signal Tachykinin Receptor Signaling Pathway Protein Kinase Activity Animal Organ Development Regulation Of Signal Transduction Kinase Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Double-stranded DNA Binding G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Release Of Cytochrome C From Mitochondria RRNA Transcription Regulation Of The Force Of Heart Contraction ATP Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Negative Regulation Of Fibroblast Proliferation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Death Programmed Cell Death Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Programmed Necrotic Cell Death Signal Transduction Fibroblast Proliferation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Relaxation Of Smooth Muscle Regulation Of Muscle System Process Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Inward Rectifier Potassium Channel Inhibitor Activity Leukocyte Activation Somitogenesis Segmentation Negative Regulation Of Lung Blood Pressure In Utero Embryonic Development Positive Regulation Of MiRNA Transcription Chordate Embryonic Development Nuclear Mineralocorticoid Receptor Binding Transcription Coactivator Binding Cell Proliferation Involved In Endocardial Cushion Morphogenesis Positive Regulation Of Tolerance Induction To Self Antigen Superior Endocardial Cushion Morphogenesis