RGS10 and GNAZ

Number of citations: 0 (PubMedID 8774883)
Data Source: HPRD (in vitro, in vivo)

		RGS10	GNAZ
Name		regulator of G protein signaling 10	G protein subunit alpha z
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body Synapse	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Cell Body Synapse
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Adenylate Cyclase Inhibitor Activity Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		G alpha (i) signalling events G alpha (i) signalling events	G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production
GWAS		Depressive symptoms (stressful life events interaction) ( 27529621 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Obstetric antiphospholipid syndrome ( 28424481 )	Handedness (Left-handed vs. non-left-handed) ( 31504236 ) Handedness (left-handed vs. right-handed) ( 31504236 ) Height ( 18391951 ) Processed meat consumption ( 32066663 )
Interacting Genes		10 interacting genes: ADRB2 APP CALM1 GNAI1 GNAI3 GNAO1 GNAZ GNRHR PLEKHF2 PRKACA	17 interacting genes: ADORA1 APP CFTR DRD2 DRD5 EYA1 EYA2 LRRK1 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7
Entrez ID		6001	2781
HPRD ID		04172	00746
Ensembl ID		ENSG00000148908	ENSG00000128266
Uniprot IDs		O43665	P19086 Q8IY73
PDB IDs		2DLR 2I59 2IHB	8DZS
GO Terms Enriched among Interactors		Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G Protein-coupled Serotonin Receptor Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of System Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Negative Regulation Of Peptide Secretion Regulation Of Protein Transport Regulation Of Peptide Hormone Secretion Modulation Of Chemical Synaptic Transmission Negative Regulation Of Protein Localization Regulation Of Transport Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Negative Regulation Of Hormone Secretion Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Blood Circulation Negative Regulation Of Protein Secretion Regulation Of Hormone Secretion Regulation Of Protein Secretion Cell Body Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Calcium-mediated Signaling GTPase Activity Signal Transduction Regulation Of Metal Ion Transport Positive Regulation Of CAMP/PKA Signal Transduction GTP Binding Negative Regulation Of Protein Transport Plasma Membrane Neuronal Dense Core Vesicle Negative Regulation Of Cell Communication Cellular Response To Oxygen-containing Compound Regulation Of Monoatomic Ion Transport Negative Regulation Of Signaling Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Transport Negative Regulation Of Establishment Of Protein Localization Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Secretion By Cell	Regulation Of Cell Communication Regulation Of Signaling Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling G-protein Alpha-subunit Binding Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Membrane Potential Histone H2AXY142 Phosphatase Activity Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Synaptic Transmission Presynaptic Membrane Dopamine Neurotransmitter Receptor Activity Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Catalytic Activity GTPase Activity Negative Regulation Of Blood Pressure Dopamine Binding Heterotrimeric G-protein Binding Plasma Membrane Phospholipase C-activating Dopamine Receptor Signaling Pathway Mesodermal Cell Fate Specification Negative Regulation Of Synaptic Transmission, Glutamatergic Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Circadian Rhythm Dendrite Postsynaptic Membrane Adult Locomotory Behavior Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of GTPase Activity Positive Regulation Of Transport Synaptic Transmission, Dopaminergic GTPase Activator Activity Long-term Synaptic Depression Associative Learning Intracellular Chemical Homeostasis Regulation Of Postsynaptic Membrane Potential Regulation Of Establishment Of Protein Localization Positive Regulation Of Cell Communication Positive Regulation Of Signaling