RGR and RDH5

Number of citations: 0 (PubMedID 11274198)
Data Source: HPRD (in vivo)

		RGR	RDH5
Name		retinal G protein coupled receptor	retinol dehydrogenase 5
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Cell Body
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Photoreceptor Activity Photoreceptor Activity	All-trans-retinol Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Androsterone Dehydrogenase [NAD(P)+] Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity 11-cis-retinol Dehydrogenase (NAD+) Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Detection Of Visible Light Cellular Response To Light Stimulus	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process
Pathways		G alpha (i) signalling events Opsins	The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway Defective visual phototransduction due to RDH5 loss of function
Drugs		None	NADH Vitamin A
Diseases		Retinitis pigmentosa (RP)	Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		High myopia ( 31816047 ) Myopia ( 27182965 ) Refractive error ( 32231278 )	Advanced age-related macular degeneration ( 26691988 ) High myopia ( 31816047 ) Macular thickness ( 30535121 ) Myopia ( 27182965 ) Refractive error ( 23396134 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 )
Novel Interactors		None recorded	2 novel interactors: FDX1 NAB2
Interacting Genes		7 interacting genes: ADRB2 CCR2 F2RL1 KIFBP RDH5 TRIM55 TRIM63	3 interacting genes: ORC4 RGR RLBP1
Entrez ID		5995	5959
HPRD ID		02642	03370
Ensembl ID		ENSG00000148604	ENSG00000135437
Uniprot IDs		A0A0S2Z494 A0A0S2Z498 P47804	Q92781
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Macrophage Migration Vasodilation Positive Regulation Of Protein-containing Complex Disassembly G Protein-coupled Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mini Excitatory Postsynaptic Potential System Process Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Type II Interferon Production Leukocyte Migration Positive Regulation Of Renin Secretion Into Blood Stream 11-cis-retinol Dehydrogenase (NAD+) Activity Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Beta2-adrenergic Receptor Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cold-induced Thermogenesis Proteinase-activated Receptor Activity Immune Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Mononuclear Cell Migration Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Regulation Of System Process Regulation Of Protein-containing Complex Disassembly Regulation Of Cytokine Production Involved In Immune Response Regulation Of Regulated Secretory Pathway Regulation Of Type II Interferon Production Positive Regulation Of Glomerular Filtration Defense Response Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Myeloid Leukocyte Migration Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Blood Vessel Diameter Maintenance Norepinephrine Binding	P450-containing Electron Transport Chain Negative Regulation Of Transcription By RNA Polymerase III Schwann Cell Differentiation Nuclear Origin Of Replication Recognition Complex Meiotic Cytokinesis Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions Visual Perception Sensory Perception Of Light Stimulus Vitamin A Metabolic Process 11-cis Retinal Binding Photoreceptor Activity G Protein-coupled Photoreceptor Activity Phosphatidylinositol Bisphosphate Binding Retinol Binding Cellular Response To Forskolin DNA Replication Origin Binding Response To Forskolin