TRIM27 and UBE2O

Number of citations: 29 (PubMedID 19549727)
Data Source: BioGRID (two hybrid)

		TRIM27	UBE2O
Name		tripartite motif containing 27	ubiquitin conjugating enzyme E2 O
Structure		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endosome Early Endosome Cytosol PML Body Retromer Complex Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol 3-kinase Inhibitor Activity	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spermatogenesis Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination Protein Sumoylation Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Suppression Of Viral Release By Host Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Positive Regulation Of Actin Nucleation Protein K63-linked Ubiquitination	Protein Monoubiquitination Protein Ubiquitination Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Protein K63-linked Ubiquitination
Pathways		SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Alopecia areata ( 25608926 ) Asthma ( 31619474 32296059 29273806 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Body size at age 10 ( 32376654 ) Brain morphology (MOSTest) ( 32665545 ) Childhood and early adolescence aggressive behavior ( 26087016 ) Daytime sleep phenotypes ( 27126917 ) Estimated glomerular filtration rate in diabetes ( 31451708 ) Experiencing mood swings ( 29500382 ) Feeling miserable ( 29500382 ) Fish- and plant-related diet ( 32066663 ) General risk tolerance (MTAG) ( 30643258 ) Hand grip strength ( 29691431 ) Heel bone mineral density ( 30598549 ) Hemoglobin levels ( 32327693 ) Liver iron content ( 34128465 ) Lung cancer in ever smokers ( 28604730 ) Neurociticism ( 29500382 ) Platelet aggregation ( 20526338 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Schizophrenia ( 30285260 ) Social communication problems ( 24047820 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 32203549 )	High light scatter reticulocyte percentage of red cells ( 32888494 ) Lymphocyte count ( 27863252 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mitochondrial DNA levels ( 25240745 ) Neutrophil percentage of white cells ( 32888494 ) Platelet distribution width ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		353 interacting genes: ABCA1 ABCF3 ABHD17A ACSF3 AEN AIRIM AMMECR1 AMOTL2 AP1M1 ARHGEF3 ARHGEF5 ARID5A ARIH2 ARMC7 ARNT2 ARPIN ATOSA ATOSB ATPAF2 ATXN7 AXIN1 BABAM1 BAG1 BAG3 BAG5 BEGAIN BEX2 BMI1 BMP7 BYSL CAPN7 CARD10 CATSPER1 CBX8 CCDC102B CCDC185 CCDC187 CCDC198 CCDC87 CCDC92 CCHCR1 CDC20B CDC23 CDC7 CDK18 CDKL3 CFAP206 CFTR CHCHD3 CHD4 CHUK CIMIP4 CKS1B CLK2 CNNM3 COX5B CPNE2 CPNE7 CREB5 CSRP2 CWF19L2 DBF4B DCX DDX6 DGCR6 DMRT3 DNMT1 DTNB DTNBP1 EHHADH EID1 EIF3D EIF3E EIF4A3 EIF4E EIF4E2 ENKD1 EPC1 ERCC3 EXOC8 FAM110A FAM161A FAM193B FAM83A FAM90A1 FANCM FARS2 FASTKD5 FBF1 FBXL19 FBXW5 FHL3 FNDC11 FOXB1 FOXC2 FXYD6 GADD45GIP1 GAS2L2 GATAD2B GCC2-AS1 GEM GFAP GFI1B GFM2 GLYCTK GNE GNPDA2 GPANK1 GPKOW GRB14 GRB2 GSE1 GTF2F1 HAPLN2 HAUS1 HCK HDAC1 HDAC4 HGS HIP1R HNRNPLL HOXB5 HOXB9 HOXC8 HR HYCC1 HYCC2 IGFN1 IKBKB IKBKE IL16 ILF2 ILK INO80B INPP5J IP6K3 IQCE IQCN IQUB JOSD1 KANSL1 KAT14 KAT5 KCTD15 KCTD9 KIF1A KIF9 KIFC3 KRT3 KRT75 KRT76 LAGE3 LASP1 LENG1 LGALS14 LINC00526 LINGO1 LMNB2 LMO1 LMO4 LNX1 LONRF1 MAD2L2 MAGEA11 MAGED4B MAGEF1 MAGOHB MAPKBP1 MAT2B MBD4 MCM7 MCOLN1 MDM2 MED21 MEMO1 MIA3 MID2 MOS MRPL40 MSRB1 MTMR6 MVP MYO15B NCK2 NCOA1 NDE1 NEBL NEDD9 NEIL2 NEK6 NELFE NIF3L1 NME7 NOTCH2NLA NR1D2 NTAQ1 NUDT21 OAS1 OGT OTUB2 P2RX7 PIAS1 PIAS2 PIAS3 PIAS4 PIBF1 PIMREG PIN1 PLEKHN1 PML POLE2 POLR1C POLR3C POM121 PPID PPL PPP1R18 PRAM1 PRKAA1 PRPF18 PRPF31 PRR35 PSMA1 PSMB1 PSMB3 PTPMT1 PTPN23 PUS7L QARS1 RAB29 RAMAC RB1 RBM23 RBM41 RBX1 RCOR3 REL RHPN1 RIBC1 RIN1 RNF213 RNF25 RNF6 RSPH14 RXRB SCNM1 SDCBP SH2D4A SHANK3 SIAH1 SIRPA SLC15A3 SMARCB1 SMARCD1 SMG9 SNRPA SNRPB2 SORBS3 SPATA2 SPATC1L SQSTM1 SRSF2 STAMBPL1 STK16 STK25 STK26 SYNGAP1 SYT17 SYT6 TACO1 TBC1D22B TCEA2 TCEANC TCHP THOC1 TLE5 TMSB4X TMSB4XP6 TNS4 TPM3 TPRKB TRAF4 TRAF5 TRIM11 TRIM21 TRIM23 TRIM29 TRIM31 TRIM32 TRIM42 TRIM43 TRIM50 TRIM55 TRIM9 TSGA10IP TSHZ3 TTLL10 TUBGCP4 TUFT1 TXNDC9 UBASH3A UBC UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2J1 UBE2K UBE2L6 UBE2N UBE2O UBE2T UBE2U UBE2W UBE2Z UBL5 UCHL3 UCHL5 UHRF2 USE1 USP2 UTP14C UTP23 VEZF1 VPS25 VPS28 VPS9D1 WT1-AS XPA YJU2 ZBTB16 ZC2HC1C ZFC3H1 ZFHX3 ZFYVE21 ZGPAT ZMYND19 ZNF250 ZNF384 ZNF414 ZNF417 ZNF446 ZNF572 ZNF580 ZNF581 ZNF587 ZNF688 ZNF79	23 interacting genes: APPL1 BAP1 CAVIN1 CPNE1 CPNE2 CPNE4 GRIK1 HEXIM1 HUNK IFRD2 ITCH MAF MDM2 MXI1 PDK1 PRKN RNF10 RNF31 SHBG TRIM27 UBA6 UBC UBE2D3
Entrez ID		5987	63893
HPRD ID		15996	10928
Ensembl ID		ENSG00000204713	ENSG00000175931
Uniprot IDs		A0A1U9X8R9 P14373	Q9C0C9
PDB IDs		Not available	7UN3 7UN6
GO Terms Enriched among Interactors		Protein Binding Ubiquitin Conjugating Enzyme Activity Nucleus Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Protein Polyubiquitination Nucleoplasm Protein Modification Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination SUMO Transferase Activity Macromolecule Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K63-linked Ubiquitination Regulation Of RNA Metabolic Process Protein Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytoplasm Ubiquitin Protein Ligase Binding Protein K6-linked Ubiquitination Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Protein Monoubiquitination Regulation Of Primary Metabolic Process Proteolysis Zinc Ion Binding PML Body Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sumoylation Transferase Activity Protein K11-linked Ubiquitination ATP Binding Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process	Protein Ubiquitination Post-translational Protein Modification Protein Autoubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Monoubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Necroptotic Process Proteolysis Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification Process Macromolecule Catabolic Process Calcium-dependent Phospholipid Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Biosynthetic Process Response To Metal Ion Cellular Response To Metal Ion Protein K29-linked Ubiquitination Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Calcium Ion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Transferase Activity Identical Protein Binding Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Intracellular Vesicle Regulation Of Viral Transcription Ubiquitin Binding Negative Regulation Of Metabolic Process Nucleus Response To Ether Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Gene Expression Endosome Membrane