PRPH2 and ROM1

Number of citations: 0 (PubMedID 10681511)
Data Source: HPRD (in vivo, in vitro)

		PRPH2	ROM1
Name		peripherin 2	retinal outer segment membrane protein 1
Structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Plasma Membrane Membrane Cell Projection	Photoreceptor Outer Segment Plasma Membrane Membrane Photoreceptor Outer Segment Membrane Cell Projection
	Molecular Function	Protein Binding Protein Homodimerization Activity	Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Adhesion Visual Perception Response To Low Light Intensity Stimulus Photoreceptor Cell Outer Segment Organization Detection Of Light Stimulus Involved In Visual Perception Protein Homooligomerization Protein Heterooligomerization Protein Maturation Retina Development In Camera-type Eye Protein Localization To Plasma Membrane	Cell Adhesion Visual Perception Regulation Of Gene Expression Photoreceptor Cell Outer Segment Organization Detection Of Light Stimulus Involved In Visual Perception Protein Homooligomerization Protein Heterooligomerization Retina Development In Camera-type Eye Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Retina Vasculature Development In Camera-type Eye Protein Localization To Photoreceptor Outer Segment
Diseases		Vitelliform macular dystrophy, including: Best disease / Juvenile vitelliform macular dystrophy (VMD2) ; Adult-onset vitelliform macular dystrophy (AVMD) Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Retinitis pigmentosa (RP)	None
GWAS		Pulse pressure ( 27841878 )	Serum bilirubin levels in metabolic syndrome ( 30621171 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		4 interacting genes: CNGB1 GRAP2 PRPH ROM1	2 interacting genes: ORMDL3 PRPH2
Entrez ID		5961	6094
HPRD ID		01553	01616
Ensembl ID		ENSG00000112619	ENSG00000149489
Uniprot IDs		P23942	Q03395
PDB IDs		7ZW1	7ZW1
GO Terms Enriched among Interactors		Photoreceptor Cell Outer Segment Organization Detection Of Light Stimulus Involved In Visual Perception Detection Of Light Stimulus Photoreceptor Outer Segment Cyclic Nucleotide-activated Monoatomic Ion Channel Activity Olfactory Nerve Maturation Detection Of Abiotic Stimulus Non-motile Cilium Membrane Detection Of Stimulus Involved In Sensory Perception Nerve Maturation Visual Perception Response To Odorant Sensory Perception Of Light Stimulus Type III Intermediate Filament Detection Of Stimulus Cell Projection Intracellularly CGMP-activated Cation Channel Activity Intracellular Cyclic Nucleotide Activated Cation Channel Complex Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Protein Localization To Photoreceptor Outer Segment Intracellularly CAMP-activated Cation Channel Activity Response To Light Stimulus Rod Photoreceptor Outer Segment Protein Localization To Non-motile Cilium Photoreceptor Outer Segment Membrane Transmembrane Transporter Complex Retina Morphogenesis In Camera-type Eye CGMP Binding Golgi-associated Vesicle Membrane Camera-type Eye Photoreceptor Cell Differentiation Retina Vasculature Development In Camera-type Eye Response To Radiation Retina Homeostasis Eye Photoreceptor Cell Differentiation Sensory Perception CAMP Binding Plasma Membrane Photoreceptor Cell Differentiation Protein Heterooligomerization Ligand-gated Monoatomic Ion Channel Activity Protein Localization To Organelle Sodium Channel Activity Terminal Bouton Photoreceptor Cell Maintenance Phototransduction Phosphotyrosine Residue Binding Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell Membrane Depolarization Ciliary Membrane Regulation Of Cytosolic Calcium Ion Concentration	Response To Low Light Intensity Stimulus Detection Of Light Stimulus Involved In Visual Perception Photoreceptor Cell Outer Segment Organization Response To Light Intensity Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Ceramide Biosynthetic Process Sphingomyelin Biosynthetic Process Intracellular Sphingolipid Homeostasis Serine Palmitoyltransferase Complex Regulation Of Sphingolipid Biosynthetic Process Regulation Of Membrane Lipid Metabolic Process Regulation Of B Cell Apoptotic Process Sphingomyelin Metabolic Process Protein Heterooligomerization Motor Behavior Negative Regulation Of Lymphocyte Apoptotic Process Photoreceptor Inner Segment Detection Of Light Stimulus Negative Regulation Of Lipid Biosynthetic Process Regulation Of Lymphocyte Apoptotic Process Regulation Of Smooth Muscle Contraction Negative Regulation Of Leukocyte Apoptotic Process Photoreceptor Outer Segment Retina Development In Camera-type Eye Ceramide Metabolic Process Sphingolipid Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Regulation Of Amide Metabolic Process Secretory Granule Membrane Specific Granule Membrane Myelination Axon Ensheathment Negative Regulation Of Lipid Metabolic Process Detection Of Abiotic Stimulus