RDH5 and RLBP1

Number of citations: 0 (PubMedID 12536149)
Data Source: BioGRID (pull down), HPRD (in vitro)

		RDH5	RLBP1
Name		retinol dehydrogenase 5	retinaldehyde binding protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle Cell Body	Nucleoplasm Cytoplasm Centrosome Cytosol Cell Body
	Molecular Function	All-trans-retinol Dehydrogenase (NAD+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Homodimerization Activity Androsterone Dehydrogenase [NAD(P)+] Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity 11-cis-retinol Dehydrogenase (NAD+) Activity	11-cis Retinal Binding Protein Binding Retinol Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process	Vitamin A Metabolic Process Visual Perception
Pathways		The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway Defective visual phototransduction due to RDH5 loss of function	The retinoid cycle in cones (daylight vision) The retinoid cycle in cones (daylight vision) The canonical retinoid cycle in rods (twilight vision) Defective visual phototransduction due to RDH5 loss of function
Drugs		NADH Vitamin A	None
Diseases		Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)	Newfoundland rod-cone dystrophy (NFRCD) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Advanced age-related macular degeneration ( 26691988 ) High myopia ( 31816047 ) Macular thickness ( 30535121 ) Myopia ( 27182965 ) Refractive error ( 23396134 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 )	Advanced age-related macular degeneration ( 28813576 ) Age-related macular degeneration (SNP x mitochondrial G12771A interaction) ( 28813576 ) Schizophrenia ( 28991256 )
Interacting Genes		3 interacting genes: ORC4 RGR RLBP1	4 interacting genes: APP KLHL8 NHERF1 RDH5
Entrez ID		5959	6017
HPRD ID		03370	01572
Ensembl ID		ENSG00000135437	ENSG00000140522
Uniprot IDs		Q92781	P12271
PDB IDs		Not available	3HX3 3HY5 4CIZ 4CJ6
GO Terms Enriched among Interactors		P450-containing Electron Transport Chain Negative Regulation Of Transcription By RNA Polymerase III Schwann Cell Differentiation Nuclear Origin Of Replication Recognition Complex Meiotic Cytokinesis Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions Visual Perception Sensory Perception Of Light Stimulus Vitamin A Metabolic Process 11-cis Retinal Binding Photoreceptor Activity G Protein-coupled Photoreceptor Activity Phosphatidylinositol Bisphosphate Binding Retinol Binding Cellular Response To Forskolin DNA Replication Origin Binding Response To Forskolin	Growth Factor Receptor Binding Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Cell Body Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Homodimerization Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization 11-cis-retinol Dehydrogenase (NAD+) Activity Lymphatic Endothelial Cell Fate Commitment Radial Pattern Formation Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Renal Phosphate Ion Absorption Negative Regulation Of Wnt Signaling Pathway Regulation Of Spontaneous Synaptic Transmission Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Cell Migration Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Microtubule-based Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Synapse Structure Or Activity Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Nervous System Process