GNB4 and GNGT1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, pull down)

		GNB4	GNGT1
Name		G protein subunit beta 4	G protein subunit gamma transducin 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Synapse Extracellular Exosome	Photoreceptor Outer Segment Photoreceptor Inner Segment Heterotrimeric G-protein Complex Plasma Membrane Membrane Photoreceptor Disc Membrane
	Molecular Function	Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding	GTPase Activity Protein Binding G-protein Beta-subunit Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Substantia Nigra Development	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phototransduction Intracellular Protein Localization Cardiac Muscle Cell Apoptotic Process Eye Photoreceptor Cell Development Cellular Response To Hypoxia
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Activation of G protein gated Potassium channels G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GWAS		Atrial fibrillation ( 29892015 30061737 ) Heart rate ( 23583979 ) Resting heart rate ( 27798624 29769521 )	Appendicular lean mass ( 33097823 ) Body mass index ( 28552196 ) Body size at age 10 ( 32376654 ) Heart rate response to recovery post exercise (10 sec) ( 29497042 ) Heart rate response to recovery post exercise (20 sec) ( 29497042 ) Heart rate response to recovery post exercise (30 sec) ( 29497042 ) Heart rate response to recovery post exercise (40 sec) ( 29497042 ) Heart rate response to recovery post exercise (50 sec) ( 29497042 ) Mosquito bite size ( 28199695 ) Resting heart rate ( 27798624 29769521 ) Taxane-induced peripheral neuropathy in breast cancer ( 29278617 )
Interacting Genes		18 interacting genes: GNAI1 GNAI2 GNAI3 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 GNGT2 MTNR1A MTNR1B PTEN UBC	14 interacting genes: GNAS GNB1 GNB2 GNB4 GNB5 GORASP2 IKBKG MSANTD4 NAGA PDCL PLEKHB1 RHO UBXN4 ZNF277
Entrez ID		59345	2792
HPRD ID		09973	01805
Ensembl ID		ENSG00000114450	ENSG00000127928
Uniprot IDs		Q9HAV0	P63211
PDB IDs		Not available	7L0P 7L0Q 7L0R 7L0S
GO Terms Enriched among Interactors		Heterotrimeric G-protein Complex G-protein Beta-subunit Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Plasma Membrane Signal Transduction Guanyl Nucleotide Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Membrane Synapse Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Melatonin Receptor Activity Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Receptor Binding PDZ Domain Binding Extracellular Exosome Response To Prostaglandin E Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Secretion By Cell Regulation Of G Protein-coupled Receptor Signaling Pathway Reproductive Behavior Negative Regulation Of Secretion Phototransduction Negative Regulation Of Insulin Secretion Midbody Negative Regulation Of Transport Negative Regulation Of Peptide Secretion Negative Regulation Of Synaptic Vesicle Clustering G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Detection Of Light Stimulus Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Hormone Secretion Multicellular Organismal Response To Stress Negative Regulation Of Protein Secretion Regulation Of Vascular Associated Smooth Muscle Cell Proliferation D2 Dopamine Receptor Binding GDP Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Cell Body Ciliary Basal Body Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep	Heterotrimeric G-protein Complex Signaling Receptor Complex Adaptor Activity G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway GTPase Activity Response To Catecholamine Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus Response To Light Intensity Photoreceptor Disc Membrane Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Sensory Perception GTPase Binding Phototransduction Alpha-N-acetylgalactosaminidase Activity Heterotrimeric G-protein Complex Assembly Rod Bipolar Cell Differentiation GTPase Activator Complex G-protein Gamma-subunit Binding Detection Of Light Stimulus Mu-type Opioid Receptor Binding Photoreceptor Outer Segment Alpha-galactosidase Activity Thermotaxis Dark Adaptation Retina Development In Camera-type Eye Signal Transduction Response To Light Stimulus Sperm Head Plasma Membrane Linear Polyubiquitin Binding Light Adaption Response To Unfolded Protein Protein-containing Complex Binding Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Lysosomal Membrane Photoreceptor Inner Segment Membrane Absorption Of Visible Light Sensory Perception Of Chemical Stimulus Cellular Response To Light Stimulus Hair Follicle Placode Formation Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Thermoception G Protein-coupled Opsin Signaling Pathway 11-cis Retinal Binding Detection Of Abiotic Stimulus Nervous System Process