TRPV4 and KRIT1

Number of citations: 0 (PubMedID 12724311)
Data Source: BioGRID (unspecified method)

		TRPV4	KRIT1
Name		transient receptor potential cation channel subfamily V member 4	KRIT1 ankyrin repeat containing
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytoplasmic Microtubule Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Membrane Apical Plasma Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane Cell Projection Anchoring Junction	Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Protein-containing Complex Anchoring Junction
	Molecular Function	Nucleotide Binding Actin Binding Osmosensor Activity Protein Kinase C Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Microtubule Binding Lipid Binding Stretch-activated, Monoatomic Cation-selective, Calcium Channel Activity Protein Kinase Binding SH2 Domain Binding Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding Actin Filament Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding GTPase Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Diet Induced Thermogenesis Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Volume Homeostasis Response To Osmotic Stress Hypotonic Response Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Neuron Projection Development Actin Cytoskeleton Organization Vasopressin Secretion Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Interleukin-6 Production Response To Insulin Monoatomic Ion Transmembrane Transport Cellular Response To Heat Hyperosmotic Salinity Response Glucose Homeostasis Positive Regulation Of Vascular Permeability Cortical Microtubule Organization Positive Regulation Of Striated Muscle Contraction Positive Regulation Of JNK Cascade Microtubule Polymerization Regulation Of Response To Osmotic Stress Positive Regulation Of Inflammatory Response Multicellular Organismal-level Water Homeostasis Transmembrane Transport Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response Cellular Hypotonic Salinity Response Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Energy Homeostasis Blood Vessel Endothelial Cell Delamination Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Negative Regulation Of Brown Fat Cell Differentiation Regulation Of Aerobic Respiration Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Endothelium Development Small GTPase-mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Integrin Activation Cell Redox Homeostasis Regulation Of Angiogenesis Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		TRP channels High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	None
Drugs		Cannabidiol Butamben Medical Cannabis Nabiximols	None
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia Distal hereditary motor neuropathies (dHMN) TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC)	Cerebral cavernous malformation
GWAS		Creatinine levels ( 29403010 ) Glomerular filtration rate ( 29403010 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 )	Coffee consumption ( 31046077 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 )
Interacting Genes		14 interacting genes: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1	7 interacting genes: ITGB1BP1 PLCB3 RAP1A RGS4 TIAM1 TRPV4 UBE2K
Entrez ID		59341	889
HPRD ID		05667	05020
Ensembl ID		ENSG00000111199	ENSG00000001631
Uniprot IDs		Q9HBA0	A4D1F7 O00522
PDB IDs		4DX1 4DX2 7AA5 8FC7 8FC8 8FC9 8FCA 8FCB 8JU5 8JU6 8JVI 8JVJ 8T1B 8T1C 8T1D 8T1E 8T1F	3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF 4TKN 5D68 6OQ3 6OQ4 6UZK 8SU8 8T09 8T7V
GO Terms Enriched among Interactors		Fc-gamma Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus T Cell Costimulation Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Signaling Receptor Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Transport Negative Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Transporter Binding Ephrin Receptor Signaling Pathway Phospholipase Activator Activity Plasma Membrane Tubulation Innate Immune Response-activating Signaling Pathway Negative Regulation Of Inflammatory Response Plasma Membrane Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Immune Response Activation Of Innate Immune Response Membrane Raft Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Actin Filament Negative Regulation Of Immune Response Cellular Response To Lectin Cellular Response To Platelet-derived Growth Factor Stimulus Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Platelet-derived Growth Factor Ephrin Receptor Binding Positive Regulation Of T Cell Activation Protein Kinase Activity Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Immune System Process Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Cell Migration	Signal Transduction Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex Regulation Of Cell Differentiation FBXO Family Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Signaling Protein Polymerization Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Calmodulin Binding Calcium Ion Transmembrane Import Into Cytosol Regulation Of Neuron Projection Development Regulation Of ERK1 And ERK2 Cascade Response To Antineoplastic Agent Anchoring Junction Negative Regulation Of Glycine Import Across Plasma Membrane Protein Kinase Binding Regulation Of Supramolecular Fiber Organization Osmosensor Activity Blood Vessel Endothelial Cell Delamination Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Stretch-activated, Monoatomic Cation-selective, Calcium Channel Activity Kinase Binding Ruffle Positive Regulation Of Cellular Component Organization Cell-matrix Adhesion Notch Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Dopamine Receptor Signaling Pathway Cellular Hypotonic Salinity Response Vasopressin Secretion Regulation Of Cell-matrix Adhesion Epithelial Cell Development Positive Regulation Of Cell-substrate Adhesion Protein-containing Complex Assembly Positive Regulation Of Protein Kinase Activity