SIGIRR and TLR5

Number of citations: 0 (PubMedID 12925853)
Data Source: HPRD (in vivo)

		SIGIRR	TLR5
Name		single Ig and TIR domain containing	toll like receptor 5
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Male Gonad Development Positive Regulation Of Interleukin-8 Production Toll-like Receptor 5 Signaling Pathway Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling	Toll Like Receptor 5 (TLR5) Cascade MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Diseases		None	Systemic lupus erythematosus
GWAS		Apolipoprotein A1 levels ( 32203549 ) Lymphocyte count ( 32888494 )	Monocyte percentage of white cells ( 32888494 )
Interacting Genes		9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	5 interacting genes: MYD88 RNF216 SIGIRR TLR1 TLR4
Entrez ID		59307	7100
HPRD ID		12018	04326
Ensembl ID		ENSG00000185187	ENSG00000187554
Uniprot IDs		C9JFX4 H0YDF8 H0YDR5 Q6IA17	A0A2R8Y7Z4 O60602
PDB IDs		Not available	3J0A 8AR2
GO Terms Enriched among Interactors		Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Defense Response Regulation Of Innate Immune Response Regulation Of Cytokine Production Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cell Surface Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Activation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Response To Interleukin-1 Positive Regulation Of Immune System Process Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Innate Immune Response Response To Lipopolysaccharide Positive Regulation Of Innate Immune Response Immune Response Regulation Of Type II Interferon Production Positive Regulation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Interleukin-1-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Regulation Of Cytokine Production Involved In Immune Response Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Immune Response-activating Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Defense Response Regulation Of JNK Cascade Response To Lipid Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Biosynthetic Process Lipopolysaccharide-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Chemokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Microglia Differentiation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-23 Production Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Inflammatory Response Detection Of Molecule Of Bacterial Origin Regulation Of Interleukin-6 Production NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Activation Of Innate Immune Response Positive Regulation Of Macrophage Cytokine Production Regulation Of Defense Response Cellular Response To Low-density Lipoprotein Particle Stimulus Detection Of Biotic Stimulus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Leukocyte Activation Involved In Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cellular Response To Lipoprotein Particle Stimulus Regulation Of Macrophage Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Macrophage Differentiation Response To Molecule Of Bacterial Origin Cell Surface Toll-like Receptor Signaling Pathway Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production JNK Cascade Positive Regulation Of Interleukin-1 Beta Production Immune Response-regulating Signaling Pathway