SIGIRR and TLR9

Number of citations: 0 (PubMedID 12925853)
Data Source: HPRD (in vivo)

		SIGIRR	TLR9
Name		single Ig and TIR domain containing	toll like receptor 9
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Golgi Membrane Extracellular Region Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Endolysosome Endolysosome Membrane Phagocytic Vesicle
	Molecular Function	Protein Binding	Interleukin-1 Receptor Binding SiRNA Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity Unmethylated CpG Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Microglial Cell Activation Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Immune System Process Positive Regulation Of Immunoglobulin Production Regulation Of Dendritic Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Canonical NF-kappaB Signal Transduction Male Gonad Development Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Maintenance Of Gastrointestinal Epithelium Positive Regulation Of B Cell Proliferation Positive Regulation Of Type I Interferon Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Regulation Of B Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Regulation Of B Cell Activation Positive Regulation Of B Cell Activation Defense Response To Virus Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Metal Ion Defense Response To Other Organism Endolysosomal Toll-like Receptor Signaling Pathway Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Cellular Response To Chloroquine Positive Regulation Of Intestinal Epithelial Cell Development
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling	PI3K Cascade Trafficking and processing of endosomal TLR Toll Like Receptor 9 (TLR9) Cascade Potential therapeutics for SARS TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome
Drugs		None	Chloroquine Hydroxychloroquine ISS-1018 Golotimod CPG 10101 Tilsotolimod
GWAS		Apolipoprotein A1 levels ( 32203549 ) Lymphocyte count ( 32888494 )	A body shape index ( 34021172 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 21926972 ) Colon cancer ( 33632709 ) Distal colorectal cancer ( 33632709 ) Feeling nervous ( 29500382 ) General cognitive ability ( 29844566 ) Parkinson's disease ( 28892059 ) Schizophrenia ( 23974872 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	6 interacting genes: BTK HRAS MAPK8IP3 RNF216 SIGIRR TLR1
Entrez ID		59307	54106
HPRD ID		12018	05685
Ensembl ID		ENSG00000185187	ENSG00000239732
Uniprot IDs		C9JFX4 H0YDF8 H0YDR5 Q6IA17	Q9NR96
PDB IDs		Not available	8AR3
GO Terms Enriched among Interactors		Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Defense Response Regulation Of Innate Immune Response Regulation Of Cytokine Production Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cell Surface Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Activation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Response To Interleukin-1 Positive Regulation Of Immune System Process Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Innate Immune Response Response To Lipopolysaccharide Positive Regulation Of Innate Immune Response Immune Response Regulation Of Type II Interferon Production Positive Regulation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Interleukin-1-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Regulation Of Cytokine Production Involved In Immune Response Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Immune Response-activating Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Defense Response Regulation Of JNK Cascade Response To Lipid Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Biosynthetic Process Lipopolysaccharide-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response	Regulation Of Cytokine Production Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Negative Regulation Of Gene Expression Immune Response-regulating Signaling Pathway Cytoplasmic Vesicle Activation Of Immune Response Toll-like Receptor Signaling Pathway Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Defense Response T Cell Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production B Cell Affinity Maturation Positive Regulation Of JNK Cascade GTPase Complex Detection Of Triacyl Bacterial Lipopeptide Toll-like Receptor 1-Toll-like Receptor 2 Protein Complex Negative Regulation Of Toll Signaling Pathway Regulation Of Signal Transduction Response To Stress Positive Regulation Of Immune Response Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Regulation Of Type I Interferon Production Phospholipase C Activator Activity Regulation Of JNK Cascade Cellular Response To Triacyl Bacterial Lipopeptide Antigen Receptor-mediated Signaling Pathway Regulation Of Interleukin-6 Production Positive Regulation Of Synoviocyte Proliferation Pattern Recognition Receptor Signaling Pathway Perinuclear Region Of Cytoplasm Cellular Response To Molecule Of Fungal Origin Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Defense Response To Other Organism Regulation Of Cell Communication