SIGIRR and IL1R1

Number of citations: 0 (PubMedID 12925853)
Data Source: HPRD (in vivo)

		SIGIRR	IL1R1
Name		single Ig and TIR domain containing	interleukin 1 receptor type 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding	Protease Binding Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Hydrolase Activity Interleukin-1 Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway Acute-phase Response Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-37 signaling	Interleukin-10 signaling Interleukin-1 signaling Potential therapeutics for SARS
Drugs		None	Anakinra SD118 OMS-103HP Foreskin fibroblast (neonatal)
GWAS		Apolipoprotein A1 levels ( 32203549 ) Lymphocyte count ( 32888494 )	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Alanine aminotransferase levels ( 33547301 ) Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Ankylosing spondylitis ( 23749187 ) Asthma ( 31959851 31619474 29785011 30929738 22561531 ) Asthma (childhood onset) ( 30929738 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Blood protein levels ( 30072576 ) C-reactive protein levels ( 30388399 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Inflammatory bowel disease ( 28067908 23128233 ) Primary biliary cholangitis ( 26394269 ) Serum protein levels (sST2) ( 23999434 ) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659 )
Interacting Genes		9 interacting genes: APP ENO2 IL1R1 IRAK1 RPN1 TLR4 TLR5 TLR9 TRAF6	11 interacting genes: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP
Entrez ID		59307	3554
HPRD ID		12018	00994
Ensembl ID		ENSG00000185187	ENSG00000115594
Uniprot IDs		C9JFX4 H0YDF8 H0YDR5 Q6IA17	B8ZZW4 P14778
PDB IDs		Not available	1G0Y 1IRA 1ITB 4DEP 4GAF
GO Terms Enriched among Interactors		Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine Production Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Defense Response Regulation Of Innate Immune Response Regulation Of Cytokine Production Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cell Surface Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Activation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Response To Interleukin-1 Positive Regulation Of Immune System Process Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of JNK Cascade Cytoplasmic Pattern Recognition Receptor Signaling Pathway Innate Immune Response Response To Lipopolysaccharide Positive Regulation Of Innate Immune Response Immune Response Regulation Of Type II Interferon Production Positive Regulation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Interleukin-1-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Regulation Of Cytokine Production Involved In Immune Response Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Immune Response-activating Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Defense Response Regulation Of JNK Cascade Response To Lipid Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Biosynthetic Process Lipopolysaccharide-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response	Interleukin-1 Receptor Binding Inflammatory Response Interleukin-1-mediated Signaling Pathway Defense Response Cytokine-mediated Signaling Pathway Response To Stress Immune Response Acute-phase Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Acute Inflammatory Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-6 Production Interleukin-1, Type I Receptor Binding Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Response To Lipopolysaccharide Fever Generation Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Molecule Of Bacterial Origin Signal Transduction Regulation Of Interleukin-6 Production Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immature T Cell Proliferation In Thymus Molecular Adaptor Activity Cell Surface Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Binding Response To Lipid Heat Generation Cellular Response To Lipid Toll Signaling Pathway Cytokine Activity Cellular Response To Oxygen-containing Compound Interleukin-33-mediated Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway Negative Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Chemokine Production Extrinsic Component Of Plasma Membrane Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signaling Adaptor Activity