RARB and NCOR2

Number of citations: 85 (PubMedID 12665583)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		RARB	NCOR2
Name		retinoic acid receptor beta	nuclear receptor corepressor 2
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcription Repressor Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Heterocyclic Compound Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Enzyme Activator Activity Nuclear Receptor Binding Nuclear Glucocorticoid Receptor Binding Histone Deacetylase Binding Nuclear Retinoic Acid Receptor Binding Protein-containing Complex Binding Nuclear Retinoid X Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Apoptotic Process Signal Transduction Cell Population Proliferation Programmed Cell Death Striatum Development Neurogenesis Cell Differentiation Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Ventricular Cardiac Muscle Cell Differentiation Bone Development Negative Regulation Of Cartilage Development Neural Precursor Cell Proliferation Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Lactation Regulation Of Ketone Metabolic Process Cerebellum Development Response To Estradiol Estrous Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of MiRNA Transcription
Pathways		Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis	PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Cytoprotection by HMOX1 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Arotinoid acid Tamibarotene LGD-1550 Trifarotene	None
Diseases		Small cell lung cancer Non-small cell lung cancer	None
GWAS		Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 ) Airflow obstruction ( 22837378 ) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360 ) Apolipoprotein A1 levels ( 32203549 ) Asthma ( 29273806 ) Bell's palsy ( 33602968 ) Blood urea nitrogen levels ( 31152163 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in smokers ( 28443625 ) Body mass index ( 28448500 28892062 25673413 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Calcium levels ( 25972035 ) Carotid intima media thickness in rheumatoid arthritis ( 30251476 ) Cataracts ( 34127677 ) Chronic obstructive pulmonary disease ( 28166215 30804561 ) Chronotype ( 30696823 ) Coffee consumption ( 31046077 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690 ) Dentures ( 31235808 ) Dietary macronutrient intake ( 29988085 ) FEV1 ( 30804560 ) General risk tolerance (MTAG) ( 30643258 ) Glaucoma (primary open-angle) ( 29891935 33627673 ) Gout ( 22179738 ) Heel bone mineral density ( 30598549 28869591 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 29785010 31959993 ) Low susceptibility to hepatitis C infection ( 31206233 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Macular thickness ( 30535121 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952 ) Molybdenum levels ( 26025379 ) Mood instability ( 31168069 ) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 ) Obesity (extreme) ( 19553259 ) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 ) Optic disc area ( 31798171 28073927 25631615 ) Optic disc size ( 31809533 ) Optic nerve head parameters (multi-trait analysis) ( 31798171 ) Peak expiratory flow ( 30804560 ) Platelet distribution width ( 32888494 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Pursuit maintenance gain ( 29064472 ) Refractive error ( 32231278 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Urinary sodium excretion ( 31409800 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065 ) Appendicular lean mass ( 33097823 ) Clubfoot ( 24667120 ) Cocaine dependence ( 23958962 ) Cognitive performance ( 19734545 ) Diastolic blood pressure ( 30224653 ) HDL cholesterol levels ( 32203549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Lung function (FEV1) ( 30061609 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Mosquito bite size ( 28199695 ) Multiple sclerosis ( 31604244 ) Platelet distribution width ( 32888494 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		24 interacting genes: ARID1A CCNDBP1 CCNH CEBPA CEBPB GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 NRIP1 PNRC1 PPARGC1A PRKD2 PSMC5 RSPH1 RXRA RXRB RXRG SMAD2 SMARCD3 SMARCE1	92 interacting genes: ADRB2 AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CAMK2B CBFA2T2 CDK2 CEBPB CEP63 CHUK CIRSR CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 H4C1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HNF4A INPP5K IRF5 JUN KLF5 KPNA4 MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PIN1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBC UBE2I VDR YWHAE ZBTB16 ZBTB5 ZBTB7A
Entrez ID		5915	9612
HPRD ID		07183	02910
Ensembl ID		ENSG00000077092	ENSG00000196498
Uniprot IDs		A0A8I5KWP3 F1D8S6 P10826 Q3SB16 Q5QHG3 Q86UC5	C9J0Q5 C9JE98 Q9Y618
PDB IDs		1HRA 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN 6SSQ	1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 2RT5 3R29 3R2A 4A69 4OAR 5X8Q 5X8X 5ZOO 5ZOP 6A22 6IVX 6PDZ 7SQA 8AQM 8AQN 8B8W 8B8X 8B8Y 8B8Z 8B90 8B91 8B92 8B93 8B94 8B95 8X7E
GO Terms Enriched among Interactors		Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Retinoic Acid Receptor Signaling Pathway Regulation Of Primary Metabolic Process DNA-templated Transcription Retinoic Acid-responsive Element Binding DNA Binding Transcription Coactivator Activity Positive Regulation Of Metabolic Process Positive Regulation Of Cell Differentiation Chromatin DNA Binding Sequence-specific DNA Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Nuclear Receptor-mediated Signaling Pathway Response To Lipid Nuclear Glucocorticoid Receptor Binding Brahma Complex Transcription Coregulator Activity NpBAF Complex Regulation Of Multicellular Organismal Development NBAF Complex Nuclear Retinoic Acid Receptor Binding Nucleobase-containing Compound Biosynthetic Process Hormone-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding C/EBP Complex DNA-binding Transcription Factor Activity Nucleosome Disassembly	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Positive Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleus DNA Binding Chromatin Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex DNA-templated Transcription Hormone-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Signal Transduction Cell Differentiation Transcription Cis-regulatory Region Binding Regulation Of Multicellular Organismal Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Transcription By RNA Polymerase II