RARB and CCNH

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		RARB	CCNH
Name		retinoic acid receptor beta	cyclin H
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Transcription Factor TFIIH Core Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex CAK-ERCC2 Complex Transcription Factor TFIIK Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Heterocyclic Compound Binding Sequence-specific Double-stranded DNA Binding	Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Regulation Of DNA-templated Transcription Apoptotic Process Signal Transduction Cell Population Proliferation Programmed Cell Death Striatum Development Neurogenesis Cell Differentiation Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Ventricular Cardiac Muscle Cell Differentiation Bone Development Negative Regulation Of Cartilage Development Neural Precursor Cell Proliferation Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Stabilization Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Arotinoid acid Tamibarotene LGD-1550 Trifarotene	None
Diseases		Small cell lung cancer Non-small cell lung cancer	None
GWAS		Adult body size ( 32376654 ) Adventurousness ( 30643258 ) Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 ) Airflow obstruction ( 22837378 ) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360 ) Apolipoprotein A1 levels ( 32203549 ) Asthma ( 29273806 ) Bell's palsy ( 33602968 ) Blood urea nitrogen levels ( 31152163 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in smokers ( 28443625 ) Body mass index ( 28448500 28892062 25673413 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Calcium levels ( 25972035 ) Carotid intima media thickness in rheumatoid arthritis ( 30251476 ) Cataracts ( 34127677 ) Chronic obstructive pulmonary disease ( 28166215 30804561 ) Chronotype ( 30696823 ) Coffee consumption ( 31046077 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690 ) Dentures ( 31235808 ) Dietary macronutrient intake ( 29988085 ) FEV1 ( 30804560 ) General risk tolerance (MTAG) ( 30643258 ) Glaucoma (primary open-angle) ( 29891935 33627673 ) Gout ( 22179738 ) Heel bone mineral density ( 30598549 28869591 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 29785010 31959993 ) Low susceptibility to hepatitis C infection ( 31206233 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Macular thickness ( 30535121 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952 ) Molybdenum levels ( 26025379 ) Mood instability ( 31168069 ) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 ) Obesity (extreme) ( 19553259 ) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 ) Optic disc area ( 31798171 28073927 25631615 ) Optic disc size ( 31809533 ) Optic nerve head parameters (multi-trait analysis) ( 31798171 ) Peak expiratory flow ( 30804560 ) Platelet distribution width ( 32888494 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Pursuit maintenance gain ( 29064472 ) Refractive error ( 32231278 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Urinary sodium excretion ( 31409800 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )	Adult body size ( 32376654 ) Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268 ) Diastolic blood pressure ( 27841878 ) Fasting glucose ( 34074324 ) Initial pursuit acceleration ( 29064472 ) Macular thickness ( 30535121 ) Major depressive disorder ( 23377640 ) Prostate cancer aggressiveness ( 25939597 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 )
Interacting Genes		24 interacting genes: ARID1A CCNDBP1 CCNH CEBPA CEBPB GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 NRIP1 PNRC1 PPARGC1A PRKD2 PSMC5 RSPH1 RXRA RXRB RXRG SMAD2 SMARCD3 SMARCE1	48 interacting genes: AR BLZF1 CALCOCO2 CCDC170 CCDC33 CCNC CCT4 CDK2 CDK20 CDK3 CDK6 CDK7 CDK8 CSNK2B CTBP2 DUSP12 ERCC3 ESR1 FUBP1 GANAB GOLGA2 GRIPAP1 GTF2E2 GTF2H1 KLC3 MCM7 MCRS1 MTA1 MTMR7 NDC80 NEDD4 PICK1 POLR2A POLR2B PPFIA1 PSMA1 RARB RHOH SFN SORBS3 SSX2IP SUPT5H TCF4 TP53 TRIM8 TRIML2 ZNF655 ZNRD2
Entrez ID		5915	902
HPRD ID		07183	09059
Ensembl ID		ENSG00000077092	ENSG00000134480
Uniprot IDs		A0A8I5KWP3 F1D8S6 P10826 Q3SB16 Q5QHG3 Q86UC5	A0A2R8YEM2 P51946
PDB IDs		1HRA 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN 6SSQ	1JKW 1KXU 6O9L 6XBZ 6XD3 7B5O 7B5Q 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 8BVW 8BYQ 8GXQ 8GXS 8ORM 8P6V 8P6W 8P6X 8P6Y 8P6Z 8P70 8P71 8P72 8P73 8P74 8P75 8P76 8P77 8P78 8P79 8PLZ 8PYR 8S0R 8S0T
GO Terms Enriched among Interactors		Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Retinoic Acid Receptor Signaling Pathway Regulation Of Primary Metabolic Process DNA-templated Transcription Retinoic Acid-responsive Element Binding DNA Binding Transcription Coactivator Activity Positive Regulation Of Metabolic Process Positive Regulation Of Cell Differentiation Chromatin DNA Binding Sequence-specific DNA Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Nuclear Receptor-mediated Signaling Pathway Response To Lipid Nuclear Glucocorticoid Receptor Binding Brahma Complex Transcription Coregulator Activity NpBAF Complex Regulation Of Multicellular Organismal Development NBAF Complex Nuclear Retinoic Acid Receptor Binding Nucleobase-containing Compound Biosynthetic Process Hormone-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding C/EBP Complex DNA-binding Transcription Factor Activity Nucleosome Disassembly	Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex DNA-templated Transcription Transcription By RNA Polymerase II Nucleoplasm Nucleus DNA Damage Response Cyclin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hormone-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Positive Regulation Of Macromolecule Biosynthetic Process Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation RNA-directed RNA Polymerase Activity RNA-templated Transcription Cytoplasm Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Division Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process G0 To G1 Transition TFIIB-class Transcription Factor Binding Chromatin Binding Positive Regulation Of Metabolic Process Viral Process Negative Regulation Of Stem Cell Proliferation DNA-templated Transcription Initiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle CKM Complex Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process DNA Repair