RAF1 and PEX5L

Number of citations: 0 (PubMedID 15302887)
Data Source: HPRD (in vitro, in vivo)

		RAF1	PEX5L
Name		Raf-1 proto-oncogene, serine/threonine kinase	peroxisomal biogenesis factor 5 like
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Pseudopodium	Cytoplasm Peroxisomal Membrane Cytosol Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Adenylate Cyclase Activator Activity Kinase Activity Transferase Activity Enzyme Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Small GTPase Binding
	Biological Process	MAPK Cascade Intracellular Glucose Homeostasis Protein Phosphorylation Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Schwann Cell Development Cell Differentiation Thyroid Gland Development Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Somatic Stem Cell Population Maintenance Regulation Of Rho Protein Signal Transduction Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Muscle Stretch ERBB2-ERBB3 Signaling Pathway Wound Healing Myelination Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Type B Pancreatic Cell Proliferation Intermediate Filament Cytoskeleton Organization Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Thymus Development Face Development Type II Interferon-mediated Signaling Pathway Death-inducing Signaling Complex Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Protein Import Into Peroxisome Matrix, Docking
Pathways		Stimuli-sensing channels Rap1 signalling GP1b-IX-V activation signalling CD209 (DC-SIGN) signaling RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling IFNG signaling activates MAPKs	None
Drugs		Sorafenib LErafAON XL281 iCo-007 Cholecystokinin Regorafenib Dabrafenib Fostamatinib	None
GWAS		A body shape index ( 34021172 ) Asthma ( 32296059 ) Cardiac hypertrophy ( 21348951 ) Carotid intima media thickness x smoking interaction ( 32117412 ) Cholesterol, total ( 20686565 24097068 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) HDL cholesterol levels ( 32203549 ) Hip index ( 34021172 ) Total cholesterol levels ( 28334899 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Bipolar disorder ( 31043756 ) Childhood body mass index ( 33045005 ) Glucose homeostasis traits ( 25524916 ) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828 ) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Type 2 diabetes ( 21490949 )
Interacting Genes		161 interacting genes: ABCB5 ADCY6 AGTR1 AKT1 AR ARNT ARRB2 BAD BAG1 BCL2 BCL2L1 BCL6 BECN1 BIRC2 BIRC3 BRAF CASZ1 CBLC CCND2 CCT3 CD44 CDC25A CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFLAR CNKSR1 COPS3 COPS7A CPS1 DCAF8 DMPK EFEMP1 ERBB2 ERBIN FGFR4 FYCO1 FYN GLIS2 GNB2 GNG4 GRB10 GRM1 HECTD3 HERC1 HGF HRAS HSP90AA1 HSP90AB1 HSPA4 HSPA8 IL2RB INSR INTS10 ITCH JAK1 JAK2 KEAP1 KRAS KRT18 KRT8 KSR1 KSR2 LATS2 LCK LRPAP1 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MAP2K6 MAP3K1 MAP3K5 MAPK1 MAPK3 MAPK7 MAPK8 MAPK8IP3 MBP MET MRAS MRC2 MYBPC1 MYC NEDD4 NF1 NF2 NPLOC4 NR3C1 NRAS NUDT14 OIP5 PACSIN3 PAK1 PAK2 PAK3 PBK PDGFRA PDGFRB PDLIM2 PEBP1 PEBP4 PEX5L PHB1 PHKA2 PIN1 PKM PPP1CC PPP2CB PRKAA1 PRKACA PRKAR1A PRKCA PRKCD PRKCE PRKCZ PRKG1 PRPF6 RANBP9 RAP1A RAP2A RASD2 RASSF1 RB1 RBBP8 RBL2 RFXANK RHEB RRAS RRAS2 RSU1 SFN SHOC2 SPRY2 SPRY4 SRC STK26 STK3 STUB1 TBXA2R TEAD2 TERT TIMM50 TMEM70 TRIM22 TSC22D3 UBE2D2 USP7 VAV1 VDAC1 WEE2-AS1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAZ YY1	3 interacting genes: HCN1 PEX7 RAF1
Entrez ID		5894	51555
HPRD ID		01265	11425
Ensembl ID		ENSG00000132155	ENSG00000114757
Uniprot IDs		A0A0S2Z4L5 A0A0S2Z559 B4E0X2 L7RRS6 P04049	Q8IYB4
PDB IDs		1C1Y 1FAQ 1FAR 1GUA 1RFA 3CU8 3IQJ 3IQU 3IQV 3KUC 3KUD 3NKX 3O8I 3OMV 4FJ3 4G0N 4G3X 4IEA 4IHL 6NTC 6NTD 6PTS 6PTW 6VJJ 6XGU 6XGV 6XHA 6XHB 6XI7 7JHP 7Z37 7Z38 8A68 8A6F 8A6H 8ATR 8ATS 8AV0 8CHF 8CPD 8EPW 8GAE 8GFT 8JOF 8JOG 8S42 8T74 8T75 8U1L 9AXA 9AXC 9AY7 9AYA	Not available
GO Terms Enriched among Interactors		Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Signal Transduction Regulation Of MAPK Cascade MAPK Cascade Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Protein Kinase Activity Cytosol Kinase Activity Nucleotide Binding Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine Kinase Activity Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process ATP Binding Protein Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Protein Phosphorylation Protein Kinase Binding Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphorylation Positive Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Protein Modification Process Regulation Of Metabolic Process Protein Tyrosine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Transferase Activity Regulation Of Multicellular Organismal Process Cellular Response To Stress Regulation Of Developmental Process Cytoplasm Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization Regulation Of Primary Metabolic Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Intracellular Protein Localization Enzyme Binding Ether Lipid Biosynthetic Process Peroxisome Matrix Targeting Signal-2 Binding Type II Interferon-mediated Signaling Pathway Insulin Secretion Involved In Cellular Response To Glucose Stimulus Adenylate Cyclase Activator Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Death-inducing Signaling Complex Assembly Neurotrophin TRK Receptor Signaling Pathway Pseudopodium Retinal Cone Cell Development Apical Dendrite Negative Regulation Of Synaptic Transmission, Glutamatergic Somatodendritic Compartment Negative Regulation Of Action Potential Regulation Of Membrane Hyperpolarization Voltage-gated Sodium Channel Activity Apical Protein Localization Intracellular CAMP-activated Cation Channel Activity Involved In Regulation Of Presynaptic Membrane Potential General Adaptation Syndrome, Behavioral Process Voltage-gated Monoatomic Cation Channel Activity HCN Channel Complex Regulation Of SA Node Cell Action Potential Intracellularly CAMP-activated Cation Channel Activity Maternal Behavior Parental Behavior Positive Regulation Of Membrane Hyperpolarization Establishment Of Protein Localization To Peroxisome Type B Pancreatic Cell Proliferation Schwann Cell Development Response To L-glutamate Ether Lipid Metabolic Process Peroxisomal Membrane Transport CAMP Binding Positive Regulation Of Peptidyl-serine Phosphorylation Face Development ERBB2 Signaling Pathway MAP Kinase Kinase Kinase Activity Endochondral Ossification Intracellular Protein Transmembrane Transport Peroxisome Organization Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Response To Muscle Stretch Thyroid Gland Development Sodium Ion Import Across Plasma Membrane