RAB27B and SYTL2

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		RAB27B	SYTL2
Name		RAB27B, member RAS oncogene family	synaptotagmin like 2
Structure
GO Annotations	Cellular Component	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm	Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Melanosome Exocytic Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatase Binding Small GTPase Binding Neurexin Family Protein Binding
	Biological Process	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport	Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Vesicle-mediated Transport
Pathways		Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Regulation of MITF-M-dependent genes involved in pigmentation
GWAS		Adult body size ( 32376654 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Body mass index ( 28892062 ) Body size at age 10 ( 32376654 ) Childhood body mass index ( 26604143 ) Depression ( 29700475 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 )	Pallidum volume ( 31530798 ) Refractive error ( 32231278 )
Interacting Genes		10 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 UNC13D	9 interacting genes: FBXO25 LNX1 MORN4 MTERF1 NRXN1 PPP1CA RAB27A RAB27B YIF1A
Entrez ID		5874	54843
HPRD ID		04846	10260
Ensembl ID		ENSG00000041353	ENSG00000137501
Uniprot IDs		O00194	A0A0U1RR07 A0A8J9FM55 Q9HCH5
PDB IDs		2F7S	3BC1 7OPP 7OPQ 7OPR 8P3G 8P3H 8P3I 8P3J 8P3K
GO Terms Enriched among Interactors		Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel	Myosin V Binding Multivesicular Body Membrane Exocytic Vesicle Multivesicular Body Sorting Pathway Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway Protein Localization To Synapse Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation G Protein Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Secretion By Cell GDP Binding Positive Regulation Of Exocytosis Protein Localization To Cell Junction Termination Of Mitochondrial Transcription Protein Complex Involved In Cell-cell Adhesion Guanylate Kinase-associated Protein Clustering Melanosome Secretory Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Complement-dependent Cytotoxicity Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Vesicle Localization Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Exosomal Secretion Secretion Negative Regulation Of Filopodium Assembly Glycogen Granule Late Endosome Establishment Of Protein Localization Weibel-Palade Body Platelet Dense Granule Membrane Cerebellar Granule Cell Differentiation Postsynaptic Density Protein 95 Clustering Neuronal Signal Transduction NMDA Selective Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Trans-synaptic Protein Complex Gephyrin Clustering Involved In Postsynaptic Density Assembly AMPA Selective Glutamate Receptor Signaling Pathway Neuroligin Family Protein Binding Type 1 Fibroblast Growth Factor Receptor Binding RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process