RAB27A and MYO5A

Number of citations: 44 (PubMedID 12006666)
Data Source: HPRD (in vitro, in vivo)

		RAB27A	MYO5A
Name		RAB27A, member RAS oncogene family	myosin VA
Structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Region Lysosome Endosome Late Endosome Golgi Apparatus Cytosol Membrane Apical Plasma Membrane Secretory Granule Dendrite Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle	Ruffle Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Cytosol Actin Filament Actin Cytoskeleton Membrane Myosin Complex Growth Cone Cytoplasmic Vesicle Vesicle Filopodium Tip Insulin-responsive Compartment Melanosome Neuron Projection Recycling Endosome Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding	Microfilament Motor Activity Nucleotide Binding RNA Binding Cytoskeletal Motor Activity Actin Binding Catalytic Activity Protein Binding Calmodulin Binding ATP Binding ATP Hydrolysis Activity Small GTPase Binding Actin Filament Binding
	Biological Process	Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Vesicle-mediated Transport Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Pigmentation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Pigment Granule Localization Pigment Granule Transport Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion	Post-Golgi Vesicle-mediated Transport Endocytosis Actin Filament Organization Protein Transport Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Melanosome Transport Cellular Response To Insulin Stimulus Protein Localization To Plasma Membrane Regulation Of Golgi Organization
Pathways		Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Regulation of MITF-M-dependent genes involved in pigmentation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Insulin processing FCGR3A-mediated phagocytosis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Fractional exhaled nitric oxide levels ( 25431337 ) Glioma ( 30714141 )	Mean platelet volume ( 32888494 ) Metabolite levels (Pyroglutamine) ( 23934736 )
Interacting Genes		28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16	20 interacting genes: AKAP9 BMF CALM1 DLGAP1 DYNLL1 DYNLL2 ERG KIF5B MLPH NDEL1 NEFL PDE4B PRPH RAB11A RAB27A RAB3A RPH3A TRIM2 TRIM3 USP7
Entrez ID		5873	4644
HPRD ID		04845	01179
Ensembl ID		ENSG00000069974	ENSG00000197535
Uniprot IDs		A2RU94 P51159	A0A8I5KTF1 A0A8J8YWI7 A8CDT9 Q9UES4 Q9Y4I1
PDB IDs		6HUF 7OPP 7OPQ 7OPR 8P3G 8P3H 8P3I 8P3J 8P3K	4D07 4J5L 4LLI 4LX1 4LX2 5JCY 5JCZ
GO Terms Enriched among Interactors		Small GTPase Binding Intracellular Transport Establishment Of Localization In Cell Secretion By Cell Exocytosis Intracellular Protein Transport Cellular Localization Protein Transport Exocytic Vesicle Vesicle-mediated Transport Neurexin Family Protein Binding Secretion Establishment Of Protein Localization Intracellular Protein Localization Regulation Of Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Exocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Regulation Of Secretion Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Melanosome Positive Regulation Of Secretion Synaptic Vesicle Docking Positive Regulation Of Regulated Secretory Pathway Regulation Of Nervous System Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Vesicle Docking Regulation Of Transport Signal Release Organelle Localization By Membrane Tethering Organelle Localization Myosin Binding Positive Regulation Of Establishment Of Protein Localization Membrane Docking Regulation Of Hormone Levels Neurotransmitter Transport Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Regulated Exocytosis Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Transport Protein Localization To Extracellular Region	Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Organelle Localization Axon Cytoplasm Myosin V Binding Establishment Of Localization In Cell Retrograde Axonal Transport Protein-containing Complex Binding Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Regulation Of Transport Centrosome Centrosome Localization Exosomal Secretion Synaptic Vesicle Transport Microtubule Associated Complex Synaptic Vesicle Membrane Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Microtubule-based Process Positive Regulation Of Regulated Secretory Pathway Lysosome Localization Transport Along Microtubule Vesicle Axonal Transport Neurofilament Cytoskeleton Organization Microtubule-based Movement Cytoskeleton-dependent Intracellular Transport Cytosol Microtubule-based Transport Axo-dendritic Transport Positive Regulation Of Exocytosis Cytoskeleton Organelle Transport Along Microtubule Protein Transport Vesicle-mediated Transport In Synapse Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Organelle Organization Secretory Granule Regulation Of Intracellular Transport Intracellular Transport Regulation Of Cellular Localization Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane