RAB1A and ADCK1

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		RAB1A	ADCK1
Name		RAB1A, member RAS oncogene family	aarF domain containing kinase 1
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Endomembrane System Membrane Transport Vesicle Membrane Melanosome Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Cadherin Binding Metal Ion Binding	Nucleotide Binding Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity
	Biological Process	Autophagosome Assembly Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endocytosis Autophagy Golgi Organization Protein Transport Vesicle-mediated Transport Cell Migration Virion Assembly Growth Hormone Secretion Melanosome Transport Positive Regulation Of Interleukin-8 Production Substrate Adhesion-dependent Cell Spreading Defense Response To Bacterium Vesicle Transport Along Microtubule Cilium Assembly COPII-coated Vesicle Cargo Loading Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process	Mitochondrion Organization Negative Regulation Of Mitochondrial Fusion Lipid Homeostasis Positive Regulation Of Cristae Formation
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	None
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494 ) Reticulocyte count ( 32888494 ) Triglyceride levels ( 32154731 )	Cerebrospinal T-tau levels ( 28247064 ) Obsessive-compulsive disorder ( 30456828 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482 ) Resting heart rate ( 27798624 )
Interacting Genes		32 interacting genes: ADCK1 CAPNS1 CDKN1A CHML CREB1 CSNK1D FNDC3B FSCN1 GOLGA2 GOLGA5 GORASP2 HIVEP1 MAPRE3 MICAL1 MICALL1 MTOR OCRL PLK1 PSMD7 RABAC1 RABEP1 RABGGTA RABGGTB RFK RUSC2 SLC16A8 SNCA SSX2IP SYT5 TBC1D17 USO1 ZNF593	2 interacting genes: EXOC5 RAB1A
Entrez ID		5861	57143
HPRD ID		01538	10630
Ensembl ID		ENSG00000138069	ENSG00000063761
Uniprot IDs		B7Z8M7 P62820 Q5U0I6	Q86TW2
PDB IDs		2FOL 2WWX 3L0I 3SFV 3TKL 4FMB 4FMC 4FMD 4FME 4IRU 4JVS 7EQ2 9MHF 9MHG 9MHH	Not available
GO Terms Enriched among Interactors		Rab-protein Geranylgeranyltransferase Complex Protein Geranylgeranylation Small GTPase Binding Golgi Organization Protein Prenylation Vesicle-mediated Transport Organelle Organization Golgi Vesicle Transport Rab Geranylgeranyltransferase Activity Protein Geranylgeranyltransferase Activity Protein Prenyltransferase Activity Cytoplasm Organelle Assembly Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cellular Localization Protein Localization To Cytoskeleton Centrosome Cycle Cis-Golgi Network Establishment Of Localization In Cell Prenyltransferase Activity Protein Destabilization Cytoplasmic Vesicle Protein Localization To Cilium Spindle Organization Cytosol Ciliary Basal Body Cadherin Binding Intracellular Transport Behavioral Response To Cocaine Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Positive Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Vesicle Fusion Establishment Of Protein Localization Cell Projection Assembly Spindle Assembly Protein Serine/threonine Kinase Binding Protein Localization To Organelle GTPase Activator Activity Chemotaxis To Arachidonate Regulation Of Protein-containing Complex Assembly Microtubule Nucleation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cilium Assembly Cellular Component Assembly Protein Localization To Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Organelle Assembly	Secretion By Cell Organelle Localization Cilium Organization Cell Projection Assembly Cilium Assembly Golgi Vesicle Transport Plasma Membrane Bounded Cell Projection Assembly Growth Hormone Secretion Secretion Virion Assembly Vesicle Tethering Involved In Exocytosis Positive Regulation Of Glycoprotein Metabolic Process Establishment Of Melanosome Localization Establishment Of Endothelial Intestinal Barrier Melanosome Localization Plasma Membrane Bounded Cell Projection Organization COPII-coated Vesicle Cargo Loading Melanosome Transport Pigment Granule Transport Organelle Assembly Exocyst Establishment Of Planar Polarity Pigment Granule Localization Vesicle Cargo Loading Vesicle Tethering Protein Transport Cell Projection Organization Vesicle Transport Along Microtubule Vesicle-mediated Transport Establishment Of Protein Localization Substrate Adhesion-dependent Cell Spreading Endothelial Cell Development Establishment Of Endothelial Barrier Epithelial Cell Apoptotic Process Membrane Fission Vesicle Docking Involved In Exocytosis Transport Vesicle Membrane Non-motile Cilium Assembly Vesicle Cytoskeletal Trafficking Positive Regulation Of Interleukin-8 Production Vesicle Docking Golgi To Plasma Membrane Transport Cellular Localization Mitotic Cytokinesis Peptide Hormone Secretion G Protein Activity Peptide Secretion Organelle Localization By Membrane Tethering Hormone Secretion Regulation Of Interleukin-8 Production