EPS15L1 and STON2

Number of citations: 50 (PubMedID 11381094)
Data Source: HPRD (two hybrid)

		EPS15L1	STON2
Name		epidermal growth factor receptor pathway substrate 15 like 1	stonin 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Of Coated Pit Presynapse	Nucleolus Cytoplasm Cytosol Synaptic Vesicle Membrane AP-2 Adaptor Complex Neuron Projection Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Cadherin Binding Metal Ion Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process	Endocytosis Endosomal Transport Synaptic Vesicle Endocytosis	Endocytosis Regulation Of Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
GWAS		Basophil count ( 32888494 ) Body size at age 10 ( 32376654 ) Eosinophil count ( 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 ) Lymphocyte count ( 32888494 27863252 29403010 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Multiple sclerosis ( 22190364 31604244 24076602 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) White blood cell count ( 27863252 21738480 32888494 ) White matter integrity ( 23218918 )	Central corneal thickness ( 29760442 32528159 ) Estimated glomerular filtration rate ( 31152163 ) Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Prudent dietary pattern ( 28644415 )
Interacting Genes		13 interacting genes: ABL1 AGFG1 AGFG2 EPN1 FCHO1 FCHO2 GNG5 LRRC7 SIM2 STON2 TRAPPC2 TRAPPC2B UBC	8 interacting genes: AP2M1 EPS15 EPS15L1 H19 ITSN1 SYT1 SYT2 UBC
Entrez ID		58513	85439
HPRD ID		09445	10531
Ensembl ID		ENSG00000127527	ENSG00000140022
Uniprot IDs		A0AAQ5BI61 Q9UBC2	A0A3B3IU55 H0YJ05 Q8WXE9
PDB IDs		Not available	2JXC
GO Terms Enriched among Interactors		Vesicle-mediated Transport Clathrin-dependent Endocytosis Endocytosis Spermatid Nucleus Differentiation Clathrin-coated Pit TRAPPII Protein Complex TRAPPIII Protein Complex Establishment Of Localization In Cell Import Into Cell TRAPP Complex Vesicle Organization Clathrin Coat Assembly COPII Vesicle Coating Acrosome Assembly Vesicle Tethering Receptor-mediated Endocytosis Vesicle Coating Synaptic Vesicle Endocytosis Presynaptic Endocytosis Protein Localization To Cytoplasmic Microtubule Plus-end Cellular Component Assembly Secretory Granule Organization Transitional One Stage B Cell Differentiation Podocyte Apoptotic Process DN4 Thymocyte Differentiation Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Protein-containing Complex Assembly Cytoplasm Intermediate Filament Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Clathrin-coated Vesicle Nicotinate-nucleotide Adenylyltransferase Activity Protein Localization To Microtubule Plus-end Intermediate Filament Cytoskeleton Organization Nucleus Organization Intermediate Filament-based Process Vesicle-mediated Transport In Synapse Protein-containing Complex Organization Microspike Assembly B-1 B Cell Homeostasis T Cell Receptor Signaling Pathway Positive Regulation Of Establishment Of T Cell Polarity Neuropilin Signaling Pathway	Vesicle-mediated Transport In Synapse Clathrin-coated Pit Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle-mediated Transport Clathrin-coated Endocytic Vesicle Membrane Postsynaptic Neurotransmitter Receptor Internalization Clathrin Coat Of Coated Pit Chromaffin Granule Membrane Postsynaptic Endocytic Zone AP-2 Adaptor Complex Calcium-dependent Activation Of Synaptic Vesicle Fusion Synapse Dense Core Granule Endocytosis Calcium Ion Sensor Activity Positive Regulation Of Dendrite Extension Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Receptor-mediated Endocytosis Low-density Lipoprotein Particle Receptor Binding Exocytic Vesicle Regulation Of Vesicle-mediated Transport Glutamatergic Synapse Clathrin-dependent Endocytosis Calcium Ion Binding Import Into Cell Protein-macromolecule Adaptor Activity Regulation Of Vesicle Fusion Regulation Of Calcium Ion-dependent Exocytosis Endosomal Transport Regulation Of Synaptic Vesicle Exocytosis Calcium-dependent Phospholipid Binding Establishment Of Localization In Cell Vesicle Organization Positive Regulation Of Transport Cytoplasmic Vesicle SNARE Binding Receptor Internalization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Endocytic Vesicle Membrane Plasma Membrane Regulation Of Neurotransmitter Secretion Clathrin-dependent Synaptic Vesicle Endocytosis Syntaxin-3 Binding Positive Regulation Of Cellular Component Organization Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter