ZNF317 and AEN

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		ZNF317	AEN
Name		zinc finger protein 317	apoptosis enhancing nuclease
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleic Acid Binding Nuclease Activity Exonuclease Activity DNA Exonuclease Activity Protein Binding Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	DNA Metabolic Process RNA Processing Apoptotic Process DNA Damage Response Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Generic Transcription Pathway Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins	None
GWAS		Night sleep phenotypes ( 27126917 )	Dupuytren's disease ( 28886342 ) Night sleep phenotypes ( 27126917 )
Interacting Genes		15 interacting genes: AEN BAHD1 CIB3 CLK2 KRT40 KRTAP10-9 NKAPD1 RBM10 RBMY1A1 RBMY1F RBMY1J ZBTB48 ZNF408 ZNF524 ZNF648	36 interacting genes: EMD EXOSC8 GNPTAB HAP1 HOMEZ IKZF1 KANK2 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 LZTS2 MBNL1 MID2 MTUS2 NKX3-1 PDE4DIP PHC2 RALYL RBMY1A1 RBMY1F RPGRIP1 SPOP SSX2IP TLE5 TRIM27 TRIM41 ZBTB43 ZBTB8A ZFP64 ZNF317 ZNF408 ZNF473
Entrez ID		57693	64782
HPRD ID		11706	08573
Ensembl ID		ENSG00000130803	ENSG00000181026
Uniprot IDs		Q96PQ6	Q8WTP8
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Positive Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Metabolic Process RNA Splicing Positive Regulation Of MRNA Metabolic Process Identical Protein Binding Spliceosomal Complex MRNA Processing RNA Processing Regulation Of RNA Metabolic Process Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus Nucleolus Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process Regulation Of Gene Expression DNA Exonuclease Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Smooth Muscle Cell Apoptotic Process Keratin Filament Negative Regulation Of Ribosome Biogenesis Nucleus Nucleic Acid Metabolic Process Regulation Of Ribosome Biogenesis Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Macromolecule Metabolic Process Response To Ionizing Radiation Smooth Muscle Cell Proliferation RNA Binding Double-stranded Telomeric DNA Binding Intermediate Filament RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding	Keratin Filament Intermediate Filament Identical Protein Binding Nucleus Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Zinc Ion Binding Regulation Of RNA Splicing Suppression Of Viral Release By Host Negative Regulation Of Viral Transcription Regulation Of Macromolecule Biosynthetic Process