TSHZ3 and MAD1L1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		TSHZ3	MAD1L1
Name		teashirt zinc finger homeobox 3	mitotic arrest deficient 1 like 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane Growth Cone Cell Projection	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nuclear Envelope Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Nuclear Pore Nuclear Basket Mitotic Spindle Mitotic Spindle Pole MAD1 Complex Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Identical Protein Binding Kinetochore Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation	Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of T Cell Proliferation Thymus Development Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Metaphase Plate Congression Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Deactivation Of Mitotic Spindle Assembly Checkpoint
Pathways		None	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		Adventurousness ( 30643258 ) Chronotype ( 30696823 ) Cognitive performance ( 19734545 ) Corneal astigmatism ( 30306274 ) Diastolic blood pressure ( 27841878 ) Falling risk ( 32999390 ) FEV1 ( 30804560 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) General risk tolerance (MTAG) ( 30643258 ) Lung function (FEV1/FVC) ( 30061609 30804560 ) Peak expiratory flow ( 30804560 ) Photic sneeze reflex ( 27182965 ) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377 ) Post bronchodilator FEV1 in COPD ( 26634245 ) Refractive error ( 32231278 ) Systemising ( 31508503 ) Systolic blood pressure ( 27841878 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )	Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 27089180 ) Alcohol consumption (drinks per week) ( 30643258 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Anxiety ( 31906708 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 21926972 34002096 28115744 27329760 ) Bitter alcoholic beverage consumption ( 31046077 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Coronary artery disease ( 29212778 33020668 ) Dimensional psychopathology (Social) ( 29496196 ) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439 ) Gastroesophageal reflux disease ( 34187846 31527586 ) General factor of neuroticism ( 30867560 ) Gut microbiota relative abundance (Streptococcus) ( 33208821 ) Hand grip strength ( 29691431 ) Idiopathic pulmonary fibrosis ( 31710517 ) Longevity ( 20834067 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269 ) Myocardial infarction ( 33532862 ) Number of sexual partners ( 30643258 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Prostate cancer ( 29892016 ) Prostate cancer (advanced) ( 29892016 ) Refractive error ( 32231278 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Rosacea symptom severity ( 29771307 ) Schizophrenia ( 30285260 22688191 28991256 23974872 29483656 ) Schizophrenia or bipolar disorder ( 24280982 ) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486 ) Sepsis (28-day mortality) ( 32592749 ) Sleep duration (short sleep) ( 30846698 ) Smoking initiation ( 33082346 ) Smoking status (ever vs never smokers) ( 30643258 ) Superior frontal gyrus volume ( 31530798 ) Superior temporal gyrus volume ( 31530798 ) Systolic blood pressure ( 30578418 ) Testicular germ cell tumor ( 28604732 23666239 28604728 ) Vaginal microbiome composition (Shannon diversity index) ( 32723796 )
Interacting Genes		30 interacting genes: ANKRA2 APBB1 APEX2 CCHCR1 CEP63 CEP70 COG6 CTBP1 CTBP2 GOLGA2 HSF2BP KASH5 KRT31 KRT40 LRRC73 MAD1L1 MRPL28 MTUS2 PIBF1 RINT1 ROPN1 SPAG5 TAX1BP1 TEPSIN TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TSC1	63 interacting genes: ALOX5 AMOTL2 ATG5 BIRC2 CAPN7 CCDC57 CCHCR1 CDC37 CDK18 CIMIP4 COIL CWF19L2 DRC4 FAM131C FAM90A1 FXR1 GPKOW HAUS1 HDAC1 HDAC2 KIF9 LENG1 LGALSL LMO1 LMO3 LNX1 MAD2L1 MAX MFAP1 MLX NDC80 NEBL NEK2 NINL NONO NTAQ1 PIBF1 PML PPP1R18 PSMA1 RNF8 SIN3A SIN3B SPATA18 SPATA2 SUPT5H SYT17 SYT6 TCAF1 TEX11 TPM1 TPM3 TPR TRIM29 TSC22D3 TSGA10 TSHZ3 TUBGCP4 UBC UBTF USP15 YJU2 ZSCAN32
Entrez ID		57616	8379
HPRD ID		18351	04065
Ensembl ID		ENSG00000121297	ENSG00000002822
Uniprot IDs		Q63HK5	Q9Y6D9
PDB IDs		2DMI	1GO4 4DZO 7B1F 7B1H 7B1J
GO Terms Enriched among Interactors		Spindle Organization Spindle Assembly Cytoskeleton Cytoplasm Identical Protein Binding Spindle Pole Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Metaphase Plate Congression DNA Damage Response White Fat Cell Differentiation Microtubule-based Process Viral Genome Replication	Cytoplasm Sin3-type Complex Nucleoplasm Protein Binding Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Chromatin Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Cell Cycle Checkpoint Spindle Assembly Nuclear Chromosome Segregation Protein Decrotonylase Activity Histone Decrotonylase Activity Muscle Thin Filament Tropomyosin Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Organization Hair Follicle Placode Formation Negative Regulation Of Stem Cell Population Maintenance Membraneless Organelle Assembly Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Cellular Response To Dopamine Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Chromosome Organization Intracellular Membraneless Organelle Negative Regulation Of RNA Metabolic Process Response To Dopamine Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Sister Chromatid Segregation Stress Fiber Centrosome Cytoskeleton Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Histone Deacetylase Complex Histone Deacetylase Activity, Hydrolytic Mechanism Kinetochore Spindle Organization Podosome Nuclear Pore Complex Assembly Microtubule-based Process Regulation Of Defense Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Calcium-dependent Phospholipid Binding Protein Lysine Deacetylase Activity