MRTFA and MYOCD

Number of citations: 0 (PubMedID 14970199)
Data Source: BioGRID (pull down), HPRD (in vitro, in vivo)

		MRTFA	MYOCD
Name		myocardin related transcription factor A	myocardin
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus
	Molecular Function	Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding	Transcription Coactivator Activity Protein Binding Histone Acetyltransferase Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Actin Cytoskeleton Organization Wound Healing, Spreading Of Cells Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Positive Regulation Of MiRNA Transcription	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth By Extracellular Stimulus Vasculogenesis Response To Hypoxia Cardiac Ventricle Development Chromatin Organization Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiocyte Differentiation Vascular Associated Smooth Muscle Cell Differentiation Cellular Component Maintenance Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Lung Alveolus Development Digestive Tract Development Smooth Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Uterus Development Urinary Bladder Development Negative Regulation Of Cell Adhesion Molecule Production Cardiac Muscle Cell Myoblast Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Ductus Arteriosus Closure Negative Regulation Of Amyloid-beta Clearance Regulation Of Phenotypic Switching Positive Regulation Of MiRNA Transcription Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways		SUMOylation of transcription cofactors RHO GTPases Activate Formins	Cardiogenesis
Drugs		Latrunculin B	None
GWAS		Appendicular lean mass ( 33097823 )	Atrial fibrillation ( 29892015 30061737 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Metabolite levels ( 23823483 ) PR interval ( 30046033 30679814 32439900 ) QRS duration ( 31251759 ) Systolic blood pressure change trajectory ( 27980656 ) Testosterone levels ( 22675492 )
Interacting Genes		12 interacting genes: KDM3A MAP1LC3A MAP1LC3B MRTFB MVP MYOCD NCOA3 SMARCA4 SRF SUMO1 TRIM54 UBE2I	11 interacting genes: GOPC GSK3B KDM3A MAMSTR MRTFA MYOD1 SMAD2 SMAD3 SMARCA4 SRF STUB1
Entrez ID		57591	93649
HPRD ID		10445	09362
Ensembl ID		ENSG00000196588	ENSG00000141052
Uniprot IDs		A0A494BZX7 A0A499FIJ6 A4FUJ8 B0QY83 Q969V6 W0Z7M9	Q8IZQ8
PDB IDs		2KVU 2KW9	Not available
GO Terms Enriched among Interactors		Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Smooth Muscle Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Small Protein Activating Enzyme Binding Regulation Of Stem Cell Population Maintenance Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Amyloid-beta Clearance Cardiac Muscle Cell Myoblast Differentiation Nuclear Pore Cellular Response To Nitrogen Starvation Transcription Coactivator Activity Cardioblast Differentiation Phosphatidylethanolamine Binding Regulation Of Transcription By RNA Polymerase II Muscle Cell Differentiation Regulation Of Amyloid-beta Clearance Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Disassembly Nuclear Androgen Receptor Binding Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Smooth Muscle Contraction Regulation Of Muscle Contraction Myoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Differentiation Glutamatergic Synapse Organelle Membrane Cardiocyte Differentiation Positive Regulation Of Stem Cell Population Maintenance Chromatin Positive Regulation Of Muscle Contraction Autophagosome Maturation Regulation Of RNA Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Regulation Of Muscle System Process Protein Sumoylation Positive Regulation Of Gene Expression, Epigenetic Serum Response Element Binding Cellular Response To Nutrient Levels SUMO Conjugating Enzyme Activity	Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of MiRNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding Chromatin Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation R-SMAD Binding Negative Regulation Of MiRNA Transcription Ubiquitin Protein Ligase Binding Paraxial Mesoderm Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Developmental Process Regulation Of Muscle Cell Differentiation Tau Protein Binding Mesoderm Formation Regulation Of RNA Metabolic Process Gastrulation Mesoderm Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Pericardium Development Regulation Of Primary Metabolic Process Formation Of Primary Germ Layer SMAD Protein Complex Trophoblast Cell Migration Regulation Of Nucleobase-containing Compound Metabolic Process Heteromeric SMAD Protein Complex Nucleoplasm Transcription Regulator Complex Embryonic Foregut Morphogenesis Regulation Of Macromolecule Metabolic Process Nodal Signaling Pathway Co-SMAD Binding Positive Thymic T Cell Selection