KLHL42 and DDI1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		KLHL42	DDI1
Name		kelch like family member 42	DDI proteasomal shuttling factor 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Spindle Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	None
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Microtubule-based Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Division	Proteolysis Proteasomal Protein Catabolic Process Regulation Of Protein Stability Cellular Response To Hydroxyurea Regulation Of DNA Stability
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	None
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Gut microbiota (functional units) ( 27694959 ) Height ( 31562340 ) Osteoarthritis (hip) ( 30664745 ) Refractive error ( 32231278 ) Resting heart rate ( 27798624 ) Type 2 diabetes ( 30054458 )	Metabolite levels ( 23823483 )
Interacting Genes		35 interacting genes: ADD1 ANKRD33 CALCOCO2 CDCA4 CKMT2 COIL CT55 CUL3 DAZAP2 DDI1 FAM168A INCA1 KRTAP19-4 MYOG OIP5 OSTF1 P4HB PFDN5 POMC RCN3 REL SERTAD1 SERTAD3 SSX2IP STAM2 STXBP4 TRIM23 TRIM54 TTC23 UBE2E3 UBQLN1 UBQLN2 UBQLN4 USHBP1 VPS52	18 interacting genes: ADRM1 CCL28 CYGB DVL2 FAM161B GPANK1 GSK3A KLHL42 MFHAS1 NCCRP1 RALGAPA2 RPP25 SDS TEKT3 TRAF2 UBC UBE2K USP2
Entrez ID		57542	414301
HPRD ID		17237	13128
Ensembl ID		ENSG00000087448	ENSG00000170967
Uniprot IDs		B2RNT7 F5H523 Q9P2K6	Q8WTU0
PDB IDs		Not available	3S8I
GO Terms Enriched among Interactors		Autophagosome Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein-containing Complex Disassembly	Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Proteolysis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of JNK Cascade Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of UDP-glucose Catabolic Process TORC2 Complex Disassembly Regulation Of Brood Size Outer Acrosomal Membrane Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor