ADGRB1 and MAGI2

Number of citations: 64 (PubMedID 23782696)
Data Source: BioGRID (pull down)

		ADGRB1	MAGI2
Name		adhesion G protein-coupled receptor B1	membrane associated guanylate kinase, WW and PDZ domain containing 2
Structure		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Extracellular Region Extracellular Space Plasma Membrane Cell-cell Junction Focal Adhesion Postsynaptic Density Membrane Cell Junction Dendrite Cell Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Anchoring Junction	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Endosome Late Endosome Centrosome Centriole Cytoskeleton Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Postsynaptic Density Membrane Dendrite Protein-containing Complex Slit Diaphragm Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Ciliary Base
	Molecular Function	Lipopolysaccharide Binding Phosphatidylserine Binding Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding PDZ Domain Binding	Protein Binding Phosphatase Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Immune System Process Phagocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Nervous System Development Axonogenesis Peripheral Nervous System Development Muscle Organ Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Catabolic Process Apoptotic Cell Clearance Engulfment Of Apoptotic Cell Innate Immune Response Regulation Of Synaptic Plasticity Defense Response To Gram-negative Bacterium Positive Regulation Of Synapse Assembly Positive Regulation Of Myoblast Fusion Positive Regulation Of Reactive Oxygen Species Biosynthetic Process	Positive Regulation Of Receptor Internalization Endocytosis Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Podocyte Development Clathrin-dependent Endocytosis Cellular Response To Nerve Growth Factor Stimulus
Pathways		None	Nephrin family interactions
GWAS		Bipolar disorder x sex interaction ( 34099189 )	Acute lymphoblastic leukemia (childhood) ( 23007406 ) Adult body size ( 32376654 ) Adverse response to drug ( 30420678 ) Airway wall thickness ( 25517131 ) Bitter beverage consumption ( 31046077 ) Body mass index ( 25673413 28892062 ) Body size at age 10 ( 32376654 ) Bronchopulmonary dysplasia ( 23897914 ) Chronotype ( 30696823 ) Computer vision syndrome ( 33941792 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444 ) General risk tolerance (MTAG) ( 30643258 ) Hippocampal atrophy ( 19668339 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535 ) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Lead levels in blood ( 25820613 ) Low density lipoprotein cholesterol levels ( 33339817 ) Mammographic density (dense area) ( 25342443 ) Memory dysfunction in frontotemporal lobe dementia ( 29724592 ) Metabolite levels ( 23823483 ) Nicotine dependence ( 33144568 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Pursuit maintenance gain ( 29064472 ) Refractive error ( 32231278 ) Response to anti-depressant treatment in major depressive disorder ( 22041458 ) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125 ) Schizophrenia ( 30285260 28991256 ) Serum folate levels ( 29953918 ) Total cholesterol levels ( 33339817 ) Visceral fat ( 30942860 )
Interacting Genes		21 interacting genes: BAIAP2 BAIAP3 DLG1 DLG4 DRD2 ELMO1 ERBB2 GPR35 GPR37 LIN7A LRRC7 MAGI1 MAGI2 MAGI3 PATJ PDZD2 PHYHIP SNTA1 SNTB1 SNTB2 SNTG2	30 interacting genes: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLGAP1 DLGAP2 DLGAP3 DLL1 DSCAM DSCAML1 DYRK3 GRID2 LCOR MORN4 PDZD11 PLEKHF2 PLXNB3 PRRG4 PTEN RAPGEF2 RIPK4 RPS6KA1 SMAD3 SNRPB TGFA VANGL2
Entrez ID		575	9863
HPRD ID		04062	16212
Ensembl ID		ENSG00000181790	ENSG00000187391
Uniprot IDs		A0A2R8Y5M7 O14514	B7Z4H4 Q86UL8
PDB IDs		Not available	1UEP 1UEQ 1UEW 1UJV 1WFV
GO Terms Enriched among Interactors		PDZ Domain Binding Plasma Membrane Dystrophin-associated Glycoprotein Complex Protein Localization To Synapse Bicellular Tight Junction Anchoring Junction Protein Localization To Cell Junction Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Cell-cell Junction Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Synapse Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein-containing Complex Localization Neuromuscular Junction Adherens Junction Cell Junction L27 Domain Binding Beta-1 Adrenergic Receptor Binding Ionotropic Glutamate Receptor Binding Syntrophin Complex Sarcolemma Postsynaptic Density MPP7-DLG1-LIN7 Complex Neuroligin Family Protein Binding Membrane Protein Localization To Membrane Cytoplasm Establishment Or Maintenance Of Cell Polarity GMP Kinase Activity Structural Molecule Activity Synaptic Membrane Lateral Plasma Membrane Peristalsis GDP Metabolic Process Regulation Of Sodium Ion Transport Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Muscle Contraction Regulation Of Receptor Internalization Regulation Of Behavior Intracellular Protein Localization Protein Localization To Cell Periphery Regulation Of Membrane Potential Postsynaptic Membrane Presynapse Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	PDZ Domain Binding Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Junction Assembly Synapse Synapse Organization Regulation Of Nervous System Development Chemical Synaptic Transmission Cell Junction Organization Signaling Postsynaptic Specialization Trans-synaptic Signaling Synaptic Signaling Postsynaptic Density Anchoring Junction System Development Regionalization Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cell Communication Anatomical Structure Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Cell-cell Junction Synapse Assembly Developmental Process Cell-cell Adhesion Mediator Activity Regulation Of Neurogenesis Glutamatergic Synapse Epithelial Tube Morphogenesis Nervous System Development Regulation Of Striated Muscle Tissue Development Cell Fate Determination Positive Regulation Of Developmental Process Pattern Specification Process Heat Generation Hepatocyte Proliferation Regulation Of Growth Regulation Of Muscle Organ Development Osteoblast Differentiation Gastrulation Embryonic Morphogenesis Animal Organ Development Positive Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Cell Junction Assembly Transcription Corepressor Binding Regulation Of Multicellular Organismal Development