MRTFB and MRTFA

Number of citations: 0 (PubMedID 14565952)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		MRTFB	MRTFA
Name		myocardin related transcription factor B	myocardin related transcription factor A
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Presynapse Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding Cadherin Binding	Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding
	Biological Process	Muscle Organ Development Cell Differentiation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Regulation Of Modification Of Postsynaptic Structure Positive Regulation Of MiRNA Transcription	Actin Cytoskeleton Organization Wound Healing, Spreading Of Cells Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation Positive Regulation Of MiRNA Transcription
Pathways		None	SUMOylation of transcription cofactors RHO GTPases Activate Formins
Drugs		None	Latrunculin B
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 )
Interacting Genes		8 interacting genes: KDM3A KPNA4 MRTFA NCOA3 SMAD1 SMAD7 SRF SVIL	12 interacting genes: KDM3A MAP1LC3A MAP1LC3B MRTFB MVP MYOCD NCOA3 SMARCA4 SRF SUMO1 TRIM54 UBE2I
Entrez ID		57496	57591
HPRD ID		17577	10445
Ensembl ID		ENSG00000186260	ENSG00000196588
Uniprot IDs		I3L2S3 Q9ULH7	A0A494BZX7 A0A499FIJ6 A4FUJ8 B0QY83 Q969V6 W0Z7M9
PDB IDs		Not available	2KVU 2KW9
GO Terms Enriched among Interactors		Male Germ Cell Nucleus Heteromeric SMAD Protein Complex Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Primary MiRNA Binding Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process I-SMAD Binding SMAD Protein Signal Transduction Muscle Tissue Development Smooth Muscle Cell Differentiation Positive Regulation Of Cartilage Development Regulation Of B Cell Antigen Processing And Presentation Regulation Of Cell Differentiation Positive Regulation Of Multicellular Organismal Process Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Type I Hypersensitivity Negative Regulation Of Antibody-dependent Cellular Cytotoxicity Ureteric Bud Development Epithelium Development Mesonephric Epithelium Development Chromatin Mesonephric Tubule Development Beta-catenin Destruction Complex Disassembly Positive Regulation Of Chondrocyte Hypertrophy Serum Response Element Binding Podosome Formaldehyde Biosynthetic Process Artery Morphogenesis Negative Regulation Of Cell Population Proliferation Cellular Developmental Process Negative Regulation Of Adaptive Immune Response Low-affinity IgG Receptor Activity Tissue Development Homomeric SMAD Protein Complex Regulation Of Cartilage Development Kidney Epithelium Development Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Chondrocyte Development Bronchus Cartilage Development Lung Smooth Muscle Development Regulation Of Stem Cell Population Maintenance PDZ Domain Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Cytotoxic T Cell Degranulation Regulation Of Multicellular Organismal Development	Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Smooth Muscle Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Small Protein Activating Enzyme Binding Regulation Of Stem Cell Population Maintenance Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Amyloid-beta Clearance Cardiac Muscle Cell Myoblast Differentiation Nuclear Pore Cellular Response To Nitrogen Starvation Transcription Coactivator Activity Cardioblast Differentiation Phosphatidylethanolamine Binding Regulation Of Transcription By RNA Polymerase II Muscle Cell Differentiation Regulation Of Amyloid-beta Clearance Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Disassembly Nuclear Androgen Receptor Binding Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Smooth Muscle Contraction Regulation Of Muscle Contraction Myoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Differentiation Glutamatergic Synapse Organelle Membrane Cardiocyte Differentiation Positive Regulation Of Stem Cell Population Maintenance Chromatin Positive Regulation Of Muscle Contraction Autophagosome Maturation Regulation Of RNA Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Regulation Of Muscle System Process Protein Sumoylation Positive Regulation Of Gene Expression, Epigenetic Serum Response Element Binding Cellular Response To Nutrient Levels SUMO Conjugating Enzyme Activity