NLN and NTS

Number of citations: 0 (PubMedID 12609826)
Data Source: HPRD (in vitro)

		NLN	NTS
Name		neurolysin	neurotensin
Structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Cytosol Plasma Membrane	Extracellular Region Transport Vesicle Cytoplasmic Vesicle Axon Terminus
	Molecular Function	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Peptide Binding Metal Ion Binding	Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Neuropeptide Receptor Binding
	Biological Process	Regulation Of Gluconeogenesis Proteolysis Peptide Metabolic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Skeletal Muscle Fiber Differentiation	Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Killing Of Cells Of Another Organism Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance
Pathways		Peptide ligand-binding receptors	Peptide ligand-binding receptors G alpha (q) signalling events
GWAS		Brain morphology (MOSTest) ( 32665545 ) Cerebrospinal fluid AB1-42 levels ( 28247064 ) Cortical surface area (MOSTest) ( 32665545 ) ghrelin levels ( 33852427 ) Logical memory (delayed recall) in mild cognitive impairment ( 29274321 ) Refractive astigmatism ( 25367360 ) Subcortical volume (MOSTest) ( 32665545 )	Metabolite levels ( 23823483 )
Interacting Genes		2 interacting genes: APP NTS	10 interacting genes: ACE2 ARRB2 CPE MEP1A MFF NLN NTSR1 NTSR2 PREP SORT1
Entrez ID		57486	4922
HPRD ID		07495	08878
Ensembl ID		ENSG00000123213	ENSG00000133636
Uniprot IDs		Q9BYT8	P30990 Q6FH20
PDB IDs		5LUZ 5LV0 8VJU 8VJV 8VJW 8VJX 8VJY	2LNE 2LNF 2LNG 2LYW 2OYV 2OYW 3F6K 4PO7 5LUZ 6UP7 8VJY
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Receptor Ligand Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Neuropeptide Receptor Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Humoral Immune Response Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding	Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Neuropeptide Signaling Pathway Metallocarboxypeptidase Activity G Protein-coupled Neurotensin Receptor Activity Metallopeptidase Activity Hormone Metabolic Process Peptidase Activity Protein Processing Proteolysis Protein Maturation Angiotensin Maturation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Amino Acid Transport Carboxypeptidase Activity Regulation Of Biological Quality Regulation Of Hormone Levels Import Into Cell Peptide Metabolic Process Neurotensin Receptor Activity, Non-G Protein-coupled Plasma Membrane Endocytic Vesicle Membrane Angiotensin Receptor Binding Clathrin-coated Pit Adult Locomotory Behavior Cytoplasmic Vesicle Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Inositol Phosphate Catabolic Process Regulation Of Amine Transport Oligopeptidase Activity Nerve Growth Factor Receptor Activity Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Regulation Of Striated Muscle Cell Differentiation Hydrolase Activity Metalloendopeptidase Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Membrane Potential Membrane Protein Localization To Secretory Granule Positive Regulation Of Gamma-aminobutyric Acid Secretion Entry Receptor-mediated Virion Attachment To Host Cell Endocytosis Amino Acid Transport Symmetric Synapse Regulation Of Skeletal Muscle Fiber Differentiation Viral Translation Viral Life Cycle