PTH2R and GRHPR

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		PTH2R	GRHPR
Name		parathyroid hormone 2 receptor	glyoxylate and hydroxypyruvate reductase
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Mitochondrion Peroxisomal Matrix Cytosol Extracellular Exosome Catalytic Complex
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding	Protein Binding Hydroxypyruvate Reductase (NADH) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Hydroxypyruvate Reductase [NAD(P)H] Activity Glyoxylate Reductase (NADPH) Activity Carboxylic Acid Binding Protein Homodimerization Activity NADP Binding NAD Binding NADPH Binding Hydroxypyruvate Reductase (NADPH) Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Carboxylic Acid Metabolic Process Dicarboxylic Acid Metabolic Process Glyoxylate Metabolic Process
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events	Glyoxylate metabolism and glycine degradation
Drugs		Parathyroid hormone	None
Diseases		None	Primary hyperoxaluria (HP)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Anthropometric traits ( 30576415 ) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334 ) Metabolite levels ( 23823483 ) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744 )	Bipolar disorder ( 31043756 ) C-reactive protein levels ( 33339817 ) Chronotype ( 30696823 ) Morning person ( 30696823 ) Severe bacterial meningitis ( 31092817 )
Interacting Genes		6 interacting genes: CALM1 DYNLT1 GRHPR HMG20A PTH PTH2	7 interacting genes: CDC7 FOS GLS2 LCOR LIG4 LSM1 PTH2R
Entrez ID		5746	9380
HPRD ID		03276	05052
Ensembl ID		ENSG00000144407	ENSG00000137106
Uniprot IDs		B4DFN8 P49190	A0A384N605 Q9UBQ7
PDB IDs		7F16	2GCG 2H1S 2Q50 2WWR
GO Terms Enriched among Interactors		Catalytic Complex Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Hydroxypyruvate Reductase [NAD(P)H] Activity Hydroxypyruvate Reductase (NADH) Activity Glyoxylate Reductase (NADPH) Activity Hydroxypyruvate Reductase (NADPH) Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Osteoclast Proliferation Negative Regulation Of Apoptotic Process In Bone Marrow Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Hormone-mediated Apoptotic Signaling Pathway Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Cell Differentiation Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Bone Mineralization Involved In Bone Maturation Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Extracellular Region Spindle Intracellular Transport Of Virus Carboxylic Acid Binding Glyoxylate Metabolic Process Negative Regulation Of Developmental Process Host Cell Secretory Vesicle Negative Regulation Of Protein Sumoylation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Peptide Hormone Receptor Binding Positive Regulation Of Inositol Phosphate Biosynthetic Process Magnesium Ion Homeostasis Titin Binding Calcium Channel Inhibitor Activity Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Response To Metal Ion Response To Parathyroid Hormone	Response To Prolactin Conditioned Taste Aversion Medium-term Memory Cellular Response To Prolactin Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity Stem Cell Population Maintenance DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Maintenance Of Cell Number Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Parathyroid Hormone Receptor Activity L-glutamine Catabolic Process Glutaminase Activity Cellular Response To Metal Ion Transcription Factor AP-1 Complex Cellular Response To Zinc Ion Starvation Nucleotide-excision Repair, DNA Gap Filling Glutamate Biosynthetic Process Lsm1-7-Pat1 Complex Response To Gravity DNA-dependent Protein Kinase-DNA Ligase 4 Complex Positive Regulation Of Nuclear Cell Cycle DNA Replication