PNPLA2 and PHYHIP

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		PNPLA2	PHYHIP
Name		patatin like domain 2, triacylglycerol lipase	phytanoyl-CoA 2-hydroxylase interacting protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane	Cytoplasm
	Molecular Function	Lipoprotein Lipase Activity Phospholipase A2 Activity Triacylglycerol Lipase Activity Protein Binding Acylglycerol O-acyltransferase Activity Hydrolase Activity Retinyl-palmitate Esterase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity	Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Acylglycerol Metabolic Process Diacylglycerol Biosynthetic Process Phototransduction, Visible Light Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Intracellular Triglyceride Homeostasis Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Lipid Homeostasis Lipid Droplet Fusion Lipid Droplet Disassembly	Intracellular Protein Localization
Pathways		Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	None
GWAS		A body shape index ( 34021172 ) Body fat distribution (arm fat ratio) ( 30664634 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Keratoconus ( 31855235 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Hypertriglyceridemia ( 23505323 )
Interacting Genes		10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2	24 interacting genes: ADGRB1 COPS6 DYRK1A EEF1A1 ERG28 FAM131A HDAC11 HNRNPA1 MAGED4B MED8 METTL18 NDRG1 NDUFV3 NFE2 PHYH PNPLA2 PPIE PRMT5 S100A13 SMARCC2 SUPT5H TTR WDR89 ZZEF1
Entrez ID		57104	9796
HPRD ID		11443	16345
Ensembl ID		ENSG00000177666	ENSG00000168490
Uniprot IDs		Q96AD5	Q92561
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of ARF Protein Signal Transduction Endomembrane System Organization Lipid Droplet Guanyl-nucleotide Exchange Factor Activity Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Small GTPase Mediated Signal Transduction	None