PNPLA2 and SERPINF1

Number of citations: 0 (PubMedID 17032652)
Data Source: BioGRID (pull down, pull down)

		PNPLA2	SERPINF1
Name		patatin like domain 2, triacylglycerol lipase	serpin family F member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane	Extracellular Region Basement Membrane Extracellular Space Axon Extracellular Matrix Melanosome Neuronal Cell Body Axon Hillock Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Lipoprotein Lipase Activity Phospholipase A2 Activity Triacylglycerol Lipase Activity Protein Binding Acylglycerol O-acyltransferase Activity Hydrolase Activity Retinyl-palmitate Esterase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Acylglycerol Metabolic Process Diacylglycerol Biosynthetic Process Phototransduction, Visible Light Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Intracellular Triglyceride Homeostasis Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Lipid Homeostasis Lipid Droplet Fusion Lipid Droplet Disassembly	Kidney Development Short-term Memory Response To Acidic PH Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Ovulation Cycle Response To Arsenic-containing Substance Positive Regulation Of Neurogenesis Retina Development In Camera-type Eye Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Cobalt Ion Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Response To Peptide
Pathways		Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	None
Drugs		None	Copper
GWAS		A body shape index ( 34021172 ) Body fat distribution (arm fat ratio) ( 30664634 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Keratoconus ( 31855235 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Blood protein levels ( 30072576 ) Calcium levels ( 20705733 )
Interacting Genes		10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2	11 interacting genes: CSNK2A1 EPM2AIP1 IMPACT KDR LRP6 MLH1 MYOC NEDD4L PNPLA2 PTPN11 SGTB
Entrez ID		57104	5176
HPRD ID		11443	01408
Ensembl ID		ENSG00000177666	ENSG00000132386
Uniprot IDs		Q96AD5	A0A140VKF3 P36955
PDB IDs		Not available	1IMV
GO Terms Enriched among Interactors		Regulation Of ARF Protein Signal Transduction Endomembrane System Organization Lipid Droplet Guanyl-nucleotide Exchange Factor Activity Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Membrane Depolarization Wnt Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of DNA Recombination Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Biological Quality Positive Regulation Of Catabolic Process Hsp90 Protein Binding Coreceptor Activity Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Nitric Oxide-cGMP Mediated Signal Transduction Cellular Developmental Process Regulation Of Mitochondrial Depolarization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Focal Adhesion Assembly Frizzled Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Skeletal Muscle Hypertrophy Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Triglyceride Metabolic Process Regulation Of Cytoplasmic Translational Initiation In Response To Stress Receptor Tyrosine Kinase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Focal Adhesion Assembly Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Cell-substrate Junction Organization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma ERBB Signaling Pathway Neutral Lipid Metabolic Process Acylglycerol Metabolic Process Intestinal Epithelial Cell Migration TRC Complex Positive Regulation Of Macroautophagy Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Cellular Response To Hydrogen Sulfide Cell Differentiation Male Meiosis Chromosome Segregation MutLalpha Complex Cerebellar Cortex Formation