PNPLA2 and ABHD5

Number of citations: 0 (PubMedID 17189257)
Data Source: BioGRID (fluorescent resonance energy transfer, protein complementation assay)

		PNPLA2	ABHD5
Name		patatin like domain 2, triacylglycerol lipase	abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane	Nucleoplasm Cytoplasm Lipid Droplet Cytosol
	Molecular Function	Lipoprotein Lipase Activity Phospholipase A2 Activity Triacylglycerol Lipase Activity Protein Binding Acylglycerol O-acyltransferase Activity Hydrolase Activity Retinyl-palmitate Esterase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Triacylglycerol Lipase Activity Protein Binding Transferase Activity Acyltransferase Activity Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity Lipase Activator Activity
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Acylglycerol Metabolic Process Diacylglycerol Biosynthetic Process Phototransduction, Visible Light Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Intracellular Triglyceride Homeostasis Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Lipid Homeostasis Lipid Droplet Fusion Lipid Droplet Disassembly	Lipid Metabolic Process Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Cell Differentiation Positive Regulation Of Lipid Catabolic Process Lipid Homeostasis
Pathways		Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Triglyceride catabolism
Diseases		None	Dorfman-Chanarin syndrome; Chanarin-Dorfman syndrome
GWAS		A body shape index ( 34021172 ) Body fat distribution (arm fat ratio) ( 30664634 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Keratoconus ( 31855235 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	A body shape index ( 34021172 ) General risk tolerance (MTAG) ( 30643258 ) Inflammatory skin disease ( 25574825 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2	21 interacting genes: CERCAM COQ8A DGAT2L6 GAD2 GET1 GRIA4 MIEF1 PCNX2 PLIN1 PLIN2 PLIN3 PNPLA2 RBFA RNF24 RUSC1 SH3GLB1 SLC44A3 TMEM14B TMEM31 TPD52L2 ZCCHC12
Entrez ID		57104	51099
HPRD ID		11443	11986
Ensembl ID		ENSG00000177666	ENSG00000011198
Uniprot IDs		Q96AD5	A0A0S2Z5D6 A0A2U3TZT9 C9J1D1 Q8WTS1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of ARF Protein Signal Transduction Endomembrane System Organization Lipid Droplet Guanyl-nucleotide Exchange Factor Activity Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Small GTPase Mediated Signal Transduction	Lipid Droplet Disassembly Lipid Droplet Positive Regulation Of Triglyceride Storage Acylglycerol Acyl-chain Remodeling Lipid Storage Lipid Droplet Organization Regulation Of Lipid Storage Cellular Response To Glucose Starvation Organelle Disassembly Positive Regulation Of Lipid Storage Glycerolipid Metabolic Process ADP Binding Protein Localization To Vacuolar Membrane Cellular Response To Starvation Response To Starvation Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity