CTNNBIP1 and CTNNA2

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		CTNNBIP1	CTNNA2
Name		catenin beta interacting protein 1	catenin alpha 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Beta-catenin Destruction Complex Protein-containing Complex Beta-catenin-ICAT Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Basolateral Plasma Membrane Catenin Complex Lamellipodium Axon Cell Projection Anchoring Junction Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse Presynaptic Active Zone Cytoplasmic Component Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Postsynaptic Density, Intracellular Component
	Molecular Function	Transcription Coactivator Binding Protein Binding Beta-catenin Binding Armadillo Repeat Domain Binding Transcription Regulator Inhibitor Activity	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Beta-catenin Binding Identical Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Ureteric Bud Morphogenesis Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Negative Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Canonical Wnt Signaling Pathway Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Cytoskeleton Organization Cell Adhesion Axonogenesis Regulation Of Neuron Projection Development Cell Migration Radial Glia Guided Migration Of Purkinje Cell Cell Differentiation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendrite Morphogenesis Brain Morphogenesis Regulation Of Synapse Structural Plasticity Prepulse Inhibition Cell-cell Adhesion Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Neuron Migration
Pathways		Deactivation of the beta-catenin transactivating complex	Myogenesis Myogenesis
GWAS		Platelet distribution width ( 32888494 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )	Adult body size ( 32376654 ) Alcohol consumption ( 28937693 ) Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767 ) Alzheimer's disease (cognitive decline) ( 23535033 ) Bipolar disorder ( 19416921 ) Body mass index ( 25673413 26426971 ) Bone mineral density (femoral neck) ( 26911590 ) Breast cancer ( 25824743 ) Cerebral microbleeds ( 31209788 ) Cerebrospinal fluid clusterin levels ( 26545630 ) Cleft palate ( 30452639 ) Cognitive function ( 25644384 ) Contrast sensitivity ( 24152035 ) Cooked vegetable consumption ( 32066663 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Fish- and plant-related diet ( 32066663 ) Gut microbiota relative abundance (Bacteroides) ( 33208821 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) LDL cholesterol levels in HIV infection ( 33109212 ) Mild influenza (H1N1) infection ( 26379185 ) Multisite chronic pain ( 31194737 33830993 ) Orthostatic hypotension ( 24124408 ) Proportion of activated microglia (inferior temporal cortex) ( 30679421 ) Protein quantitative trait loci ( 18464913 ) Raw vegetable consumption ( 32066663 ) Refractive error ( 32231278 ) Response to cytadine analogues (cytosine arabinoside) ( 24483146 ) Response to lurasidone in schizophrenia ( 29730043 ) Schizophrenia (MTAG) ( 32107650 ) Survival in pancreatic cancer ( 28470677 )
Interacting Genes		19 interacting genes: BEND5 CTNNA2 CTNNB1 EMD GINS4 INCA1 JUP KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP5-9 MSS51 NBPF19 NOTCH2NLA P4HA3 REL SPATA24 TCF7L2 USHBP1	3 interacting genes: CCDC88A CTNNBIP1 PTPN14
Entrez ID		56998	1496
HPRD ID		09677	00228
Ensembl ID		ENSG00000178585	ENSG00000066032
Uniprot IDs		Q9NSA3	F6KRI5 P26232 Q49AD3
PDB IDs		1LUJ 1M1E 1T08	6DUW
GO Terms Enriched among Interactors		Catenin-TCF7L2 Complex Intermediate Filament Catenin Complex Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-TCF7L2 Complex Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Proteoglycan Biosynthetic Process Cellular Response To Indole-3-methanol Protein-DNA Complex Response To Indole-3-methanol Nuclear Receptor Binding Alpha-catenin Binding Presynaptic Active Zone Cytoplasmic Component Beta-catenin-TCF Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Fibroblast Proliferation Keratin Filament Postsynaptic Density, Intracellular Component Canonical Wnt Signaling Pathway Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Cadherin Binding Pancreas Development Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Wnt Signaling Pathway Regulation Of Glycoprotein Biosynthetic Process Adherens Junction Detection Of Mechanical Stimulus Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation TMEM240-body Gamma-catenin-TCF7L2 Complex Intercalated Disc Transcription Corepressor Binding Skin Development Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Positive Regulation Of Nucleocytoplasmic Transport	Regulation Of Protein Localization Maintenance Of Protein Location In Plasma Membrane Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Beta-catenin-ICAT Complex