XAB2 and GLIS2

Number of citations: 20 (PubMedID 17289029)
Data Source: BioGRID (two hybrid)

		XAB2	GLIS2
Name		XPA binding protein 2	GLIS family zinc finger 2
Structure			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Non-motile Cilium
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Blastocyst Development DNA Repair Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription RNA Processing MRNA Processing DNA Damage Response RNA Splicing Cerebral Cortex Development	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Involved In Kidney Development Hematopoietic Stem Cell Homeostasis Positive Regulation Of Protein Localization To Nucleus
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	None
Diseases		None	Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		No GWAS studies recorded	Erectile dysfunction ( 30583798 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lung function (FEV1/FVC) ( 26635082 ) Prostate-specific antigen levels ( 28139693 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		18 interacting genes: CACHD1 DHX16 DSCR9 ERCC6 ERCC8 GLIS2 ILF3 MIR106B MIR34B MIRLET7E MIRLET7G MIRLET7I POLR2A PPIE RNF10 SMAD9 SUMO2 XPA	92 interacting genes: ACTMAP ACTN3 AKAP9 AKT1 ANKRD36B ARAF ARID5A ARNT BCAR1 BECN1 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CREM CRX CSNK2B CTBP2 CTNNB1 EPHA2 ERBB2 FAM168B FGFR4 FOSB FZR1 GLIS1 GMNN GOLGA6L9 GPSM1 GPSM2 HGF HIF1A KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP8-1 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NME7 NSD3 OIP5 PIK3CA PLEKHB1 PLEKHB2 POU6F2 PRKAR1B PRR20A PRR20B PRR20C PRR20D PRR20E RAF1 RASSF1 RBFOX2 RBM11 RBPMS SHOX SOX3 SPECC1L STK11 TEAD2 TENT5A TERT TLE5 TRIM32 TSC1 TWIST2 U2AF2 VAC14 VBP1 VENTX WNK1 WT1 WWOX XAB2 ZRANB1
Entrez ID		56949	84662
HPRD ID		18306	12256
Ensembl ID		ENSG00000076924	ENSG00000126603
Uniprot IDs		Q9HCS7	B3KTH4 Q9BZE0
PDB IDs		5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7ABI 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	Not available
GO Terms Enriched among Interactors		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulatory NcRNA-mediated Gene Silencing RISC Complex Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Metabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Transcription-coupled Nucleotide-excision Repair MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding Response To X-ray Positive Regulation Of MRNA Metabolic Process Response To UV Base-excision Repair Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Gene Expression Regulation Of Transcription-coupled Nucleotide-excision Repair Site Of DNA Damage Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Translation Nucleotide-excision Repair, DNA Damage Recognition Regulation Of MRNA Stability MRNA Splicing, Via Spliceosome Positive Regulation Of Transcription By RNA Polymerase II RNA Splicing, Via Transesterification Reactions Regulation Of RNA Stability MiRNA-mediated Gene Silencing By Inhibition Of Translation DNA-templated Transcription Elongation Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein	Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Kinase Activity Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Response To Growth Factor Protein Kinase Activity Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Signal Transduction Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Binding Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Animal Organ Development MAPK Cascade Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction