XAB2 and ERCC8

Number of citations: 0 (PubMedID 10944529)
Data Source: HPRD (in vitro, in vivo)

		XAB2	ERCC8
Name		XPA binding protein 2	ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Chromosome Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Perikaryon Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Protein Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Blastocyst Development DNA Repair Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription RNA Processing MRNA Processing DNA Damage Response RNA Splicing Cerebral Cortex Development	Single Strand Break Repair Protein Polyubiquitination DNA Repair Transcription-coupled Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Response To UV Response To X-ray Response To Auditory Stimulus Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair Protein Autoubiquitination Regulation Of Transcription-coupled Nucleotide-excision Repair Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Diseases		None	Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		No GWAS studies recorded	Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		18 interacting genes: CACHD1 DHX16 DSCR9 ERCC6 ERCC8 GLIS2 ILF3 MIR106B MIR34B MIRLET7E MIRLET7G MIRLET7I POLR2A PPIE RNF10 SMAD9 SUMO2 XPA	12 interacting genes: CAMK2D CBR1 CSNK2B DDB1 ERCC6 GTF2H2 POLR2A RBX1 TOP1 UQCRQ UVSSA XAB2
Entrez ID		56949	1161
HPRD ID		18306	07523
Ensembl ID		ENSG00000076924	ENSG00000049167
Uniprot IDs		Q9HCS7	A0A0S2Z3L1 B3KPW7 B4DGZ9 Q13216
PDB IDs		5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7ABI 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	4A11 6FCV 7OO3 7OOB 7OOP 7OPC 7OPD 8B3D 8B3F 8B3G 8B3I 8QH5 9BZ0 9ER2 9FD2
GO Terms Enriched among Interactors		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulatory NcRNA-mediated Gene Silencing RISC Complex Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Metabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Transcription-coupled Nucleotide-excision Repair MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding Response To X-ray Positive Regulation Of MRNA Metabolic Process Response To UV Base-excision Repair Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Gene Expression Regulation Of Transcription-coupled Nucleotide-excision Repair Site Of DNA Damage Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Translation Nucleotide-excision Repair, DNA Damage Recognition Regulation Of MRNA Stability MRNA Splicing, Via Spliceosome Positive Regulation Of Transcription By RNA Polymerase II RNA Splicing, Via Transesterification Reactions Regulation Of RNA Stability MiRNA-mediated Gene Silencing By Inhibition Of Translation DNA-templated Transcription Elongation Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein	Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Response To UV DNA Metabolic Process Response To Radiation DNA-templated Transcription DNA Repair Response To Light Stimulus Site Of DNA Damage Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cul4B-RING E3 Ubiquitin Ligase Complex DNA-templated Transcription Elongation DNA Damage Response Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Metabolic Process Macromolecule Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Prp19 Complex Transcription By RNA Polymerase II Nucleoplasm Base-excision Repair, AP Site Formation Protein Modification Process Chromatin-protein Adaptor Activity Nucleobase-containing Compound Metabolic Process Cullin Family Protein Binding Cul4-RING E3 Ubiquitin Ligase Complex RNA Metabolic Process Macromolecule Biosynthetic Process Protein Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transcription Elongation By RNA Polymerase II Cellular Response To Stress Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Type I Interferon-mediated Signaling Pathway Response To Gamma Radiation Pons Development Subthalamus Development Protein Ubiquitination Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Interferon-mediated Signaling Pathway 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADPH) Activity Protein Modification By Small Protein Conjugation Chromosome Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Dense Fibrillar Component Generation Of Catalytic Spliceosome For First Transesterification Step RNA Polymerase Inhibitor Activity