DUSP22 and MAPK8

Number of citations: 0 (PubMedID 12138158)
Data Source: HPRD (in vivo)

		DUSP22	MAPK8
Name		dual specificity phosphatase 22	mitogen-activated protein kinase 8
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Filamentous Actin Leading Edge Of Lamellipodium	Nucleus Nucleoplasm Cytoplasm Cytosol Axon Synapse Basal Dendrite
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Protein Tyrosine Kinase Inhibitor Activity Protein Tyrosine Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Phosphatase Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of JNK Cascade T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Focal Adhesion Assembly Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus	MAPK Cascade Double-strand Break Repair Protein Phosphorylation Response To Oxidative Stress JNK Cascade JUN Phosphorylation Response To UV Response To Mechanical Stimulus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Cyclase Activity Positive Regulation Of Cell Killing Negative Regulation Of Protein Binding Regulation Of Protein Localization Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability NLRP3 Inflammasome Complex Assembly Rhythmic Process Positive Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade MRNA Destabilization Protein Poly-ADP-ribosylation Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Senescence Energy Homeostasis Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Localization To Site Of Double-strand Break
Pathways		None	Activation of BIM and translocation to mitochondria Activation of BMF and translocation to mitochondria NRAGE signals death through JNK NRAGE signals death through JNK NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-38 signaling WNT5:FZD7-mediated leishmania damping Signaling by ALK fusions and activated point mutants
Drugs		None	Tamoxifen Minocycline Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide Halicin
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Albumin-globulin ratio ( 29403010 ) Alopecia areata ( 25608926 ) Asthma (childhood onset) ( 31036433 ) Crohn's disease ( 26192919 ) Eosinophil count ( 32888494 ) Inflammatory bowel disease ( 26192919 ) Male-pattern baldness ( 28196072 ) Non-albumin protein levels ( 29403010 ) Serum total protein levels ( 29403010 ) Systemic lupus erythematosus ( 33536424 ) Takayasu arteritis ( 30498034 )	Blood protein levels in cardiovascular risk ( 28369058 ) Daytime sleep phenotypes ( 27126917 ) Opioid dependence (time to event) ( 34124712 ) Refractive error ( 32231278 )
Interacting Genes		6 interacting genes: HOXA1 MAP2K4 MAP2K7 MAPK14 MAPK8 PTP4A2	140 interacting genes: AIMP1 AKT1 APBB2 APLP2 APP ATF2 ATM BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 EEF2K EGFR ELK1 ELK3 ELK4 ELP1 EP300 ETV1 FAM193B FZR1 GANAB GARS1 GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A1 H2AX HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K2 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MBP METTL3 MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NFE2L2 NKAPD1 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCA SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219 ZNF605
Entrez ID		56940	5599
HPRD ID		13255	03100
Ensembl ID		ENSG00000112679	ENSG00000107643
Uniprot IDs		A0A384NLC8 Q9NRW4	A1L4K2 P45983
PDB IDs		1WRM 4WOH 6L1S 6LMY 6LOT 6LOU 6LVQ 7C8S	1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS 4HYU 4IZY 4L7F 4QTD 4UX9 4YR8 5LW1 6F5E 6ZR5 8PT8 8PT9 8PTA 8R5E 8X5M 9FT9
GO Terms Enriched among Interactors		Cellular Senescence MAP Kinase Activity MAP Kinase Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Fc-epsilon Receptor Signaling Pathway JUN Kinase Kinase Activity MAPK Cascade Fc Receptor Signaling Pathway JNK Cascade Response To Light Stimulus Protein Serine Kinase Activity Protein Phosphatase Binding Protein Serine/threonine Kinase Activity Response To Radiation Protein Kinase Activity Regulation Of Motor Neuron Apoptotic Process Response To UV Cellular Response To Lipopolysaccharide Positive Regulation Of Cyclase Activity Kinase Activity Cellular Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Canonical Inflammasome Complex Assembly Intracellular Signaling Cassette Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Immune Response Response To Molecule Of Bacterial Origin Enzyme Binding Energy Homeostasis Immune Response-regulating Signaling Pathway Cellular Response To Mechanical Stimulus Semicircular Canal Formation JUN Phosphorylation Cellular Response To Lipid ATP Binding Abducens Nerve Formation Optokinetic Behavior Response To Tumor Necrosis Factor Protein Tyrosine Kinase Activity Cellular Response To Stress Regulation Of Immune System Process Regulation Of Synaptic Membrane Adhesion JUN Kinase Activity Smooth Muscle Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Transferase Activity Nucleotide Binding Intracellular Signal Transduction	Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Signal Transduction MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Stress Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Cellular Developmental Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Response To Growth Factor Regulation Of Signaling Cellular Response To Oxygen-containing Compound Regulation Of Cell Communication Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of MAPK Cascade Regulation Of Transcription By RNA Polymerase II Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Hormone Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Programmed Cell Death Cell Death Regulation Of Cell Differentiation