DUSP22 and MAPK14

Number of citations: 0 (PubMedID 11346645)
Data Source: HPRD (in vitro, in vivo)

		DUSP22	MAPK14
Name		dual specificity phosphatase 22	mitogen-activated protein kinase 14
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Filamentous Actin Leading Edge Of Lamellipodium	Spindle Pole Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Speck Secretory Granule Lumen Glutamatergic Synapse Ficolin-1-rich Granule Lumen
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Protein Tyrosine Kinase Inhibitor Activity Protein Tyrosine Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase P38 Binding NFAT Protein Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of JNK Cascade T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Focal Adhesion Assembly Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus	DNA Damage Checkpoint Signaling MAPK Cascade Cell Morphogenesis Cartilage Condensation Angiogenesis Osteoblast Differentiation Placenta Development Response To Dietary Excess Chondrocyte Differentiation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Glucose Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Chemotaxis DNA Damage Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Skeletal Muscle Tissue Development Positive Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Fatty Acid Oxidation Platelet Activation Regulation Of Ossification Osteoclast Differentiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Response To Muramyl Dipeptide Response To Lipopolysaccharide Positive Regulation Of Interleukin-12 Production Response To Insulin Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Muscle Stretch P38MAPK Cascade Positive Regulation Of Protein Import Into Nucleus Signal Transduction In Response To DNA Damage Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II D-glucose Import Positive Regulation Of D-glucose Import Vascular Endothelial Growth Factor Receptor Signaling Pathway Stem Cell Differentiation Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Protein Maturation Positive Regulation Of Cardiac Muscle Cell Proliferation Bone Development Pyroptotic Inflammatory Response 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Cellular Response To UV-B Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Brown Fat Cell Differentiation Cellular Senescence Stress-induced Premature Senescence Cellular Response To Virus Regulation Of Synaptic Membrane Adhesion Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myoblast Fusion NLRP1 Inflammasome Complex Assembly Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		None	NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A CD163 mediating an anti-inflammatory response Regulation of MITF-M-dependent genes involved in pigmentation
Drugs		None	Minocycline Dasatinib 4-[5-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine N-[(3Z)-5-Tert-butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene]-N'-(4-chlorophenyl)urea 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One Inhibitor of P38 Kinase 6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine 3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine 1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea 3-(Benzyloxy)Pyridin-2-Amine l)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One 4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline Doramapimod 2-Chlorophenol 4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole SB220025 4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE Triazolopyridine KC706 Talmapimod VX-702 R-1487 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide Neflamapimod N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE 4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide PH-797804 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine SD-0006 N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO- 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE 3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE 3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE Fostamatinib
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Albumin-globulin ratio ( 29403010 ) Alopecia areata ( 25608926 ) Asthma (childhood onset) ( 31036433 ) Crohn's disease ( 26192919 ) Eosinophil count ( 32888494 ) Inflammatory bowel disease ( 26192919 ) Male-pattern baldness ( 28196072 ) Non-albumin protein levels ( 29403010 ) Serum total protein levels ( 29403010 ) Systemic lupus erythematosus ( 33536424 ) Takayasu arteritis ( 30498034 )	Foot ulcer in diabetes and neuropathy ( 28672053 ) Height ( 33713608 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		6 interacting genes: HOXA1 MAP2K4 MAP2K7 MAPK14 MAPK8 PTP4A2	173 interacting genes: AIMP1 ARNT ATF2 ATM BCL2 BCL2L1 BICD1 BMI1 BTG2 BTRC CCDC14 CCDC97 CCND2 CD4 CDC25A CDC25B CDC25C CDK4 CDK6 CDKN2A CDT1 CDX2 CENPC CEP164 COPS5 CREB1 CSNK2A1 CSNK2A2 CSNK2B DAB1 DDIT3 DUSP1 DUSP10 DUSP16 DUSP2 DUSP22 DUSP4 DUSP7 DUSP9 DYRK1B EEA1 EEF1A1 EEF2K EGFR EIF4EBP1 ELK1 ELK3 EPB42 EPHA2 EPS15 ESR1 ETV1 FGFR4 FKBP8 FLNA GADD45A GATA3 GDF15 GMFB GORASP2 GRB2 HDAC3 HIVEP1 HNF4A HSF4 HSPB1 HTRA2 ILKAP INTS6L IRAK1 JDP2 JUN JUNB KAT2A KAT2B KMT2C KRT18 KRT8 LATS2 LIMK1 MAFA MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K10 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPT MARS1 MAX MBP MEF2A MEF2C MEF2D METTL3 MIDEAS MITF MKNK1 MKNK2 MOB3B MUC12 MYC NCOA3 NF2 NFATC1 NFATC4 NFIC NGB NKTR NLRP1 NRL NUP153 PAK6 PHC2 PI4K2B PIAS2 PLA2G4A PLG PML PPARGC1A PPP4R3A PTPN7 RB1 RBSN RELA RET ROBO1 RPL22 RPL41 RPS6KA4 RPS6KA5 S100A9 SCN8A SH2D1A SHC1 SLC9A1 SMAD3 SMAD7 SMARCD3 SNAPIN SP7 SPAG9 SPTBN1 SQSTM1 SRPK1 SRSF5 STAT1 STAT4 STK11 STK39 SUPT20H TAB1 TCF20 TFCP2 TLE5 TMEM63B TP53 TRAF6 TSC1 UBC UGT2B10 ULK1 YY1AP1 ZFP36L1 ZNF142 ZNHIT1
Entrez ID		56940	1432
HPRD ID		13255	02619
Ensembl ID		ENSG00000112679	ENSG00000112062
Uniprot IDs		A0A384NLC8 Q9NRW4	B4E0K5 L7RSM2 Q16539
PDB IDs		1WRM 4WOH 6L1S 6LMY 6LOT 6LOU 6LVQ 7C8S	1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2FSL 2FSM 2FSO 2FST 2GFS 2I0H 2LGC 2NPQ 2OKR 2ONL 2QD9 2RG5 2RG6 2Y8O 2YIS 2YIW 2YIX 2ZAZ 2ZB0 2ZB1 3BV2 3BV3 3BX5 3C5U 3CTQ 3D7Z 3D83 3DS6 3DT1 3E92 3E93 3FC1 3FI4 3FKL 3FKN 3FKO 3FL4 3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK 3FML 3FMM 3FMN 3FSF 3FSK 3GC7 3GCP 3GCQ 3GCS 3GCU 3GCV 3GFE 3GI3 3HA8 3HEC 3HEG 3HL7 3HLL 3HP2 3HP5 3HRB 3HUB 3HUC 3HV3 3HV4 3HV5 3HV6 3HV7 3HVC 3IPH 3ITZ 3IW5 3IW6 3IW7 3IW8 3K3I 3K3J 3KF7 3KQ7 3L8S 3L8X 3LFA 3LFB 3LFC 3LFD 3LFE 3LFF 3LHJ 3MGY 3MH0 3MH1 3MH2 3MH3 3MPA 3MPT 3MVL 3MVM 3MW1 3NEW 3NNU 3NNV 3NNW 3NNX 3NWW 3O8P 3O8T 3O8U 3OBG 3OBJ 3OC1 3OCG 3OD6 3ODY 3ODZ 3OEF 3PG3 3QUD 3QUE 3RIN 3ROC 3S3I 3S4Q 3U8W 3UVP 3UVQ 3UVR 3ZS5 3ZSG 3ZSH 3ZSI 3ZYA 4A9Y 4AA0 4AA4 4AA5 4AAC 4DLI 4DLJ 4E5A 4E5B 4E6A 4E6C 4E8A 4EH2 4EH3 4EH4 4EH5 4EH6 4EH7 4EH8 4EH9 4EHV 4EWQ 4F9W 4F9Y 4FA2 4GEO 4KIN 4KIP 4KIQ 4L8M 4R3C 4ZTH 5ETA 5ETC 5ETF 5ETI 5ML5 5MTX 5MTY 5MZ3 5N63 5N64 5N65 5N66 5N67 5N68 5O8U 5O8V 5OMG 5OMH 5TBE 5TCO 5WJJ 5XYX 5XYY 6ANL 6HWT 6HWU 6HWV 6M95 6M9L 6OHD 6QDZ 6QE1 6QYX 6RFO 6SFI 6SFJ 6SFK 6SFO 6TCA 6ZQS 6ZWP 8A8M 8VXE 8X3M 8YD9 9CJ1 9CJ2 9CJ3 9CJ4 9CJ5 9MHB
GO Terms Enriched among Interactors		Cellular Senescence MAP Kinase Activity MAP Kinase Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Fc-epsilon Receptor Signaling Pathway JUN Kinase Kinase Activity MAPK Cascade Fc Receptor Signaling Pathway JNK Cascade Response To Light Stimulus Protein Serine Kinase Activity Protein Phosphatase Binding Protein Serine/threonine Kinase Activity Response To Radiation Protein Kinase Activity Regulation Of Motor Neuron Apoptotic Process Response To UV Cellular Response To Lipopolysaccharide Positive Regulation Of Cyclase Activity Kinase Activity Cellular Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Canonical Inflammasome Complex Assembly Intracellular Signaling Cassette Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Lipopolysaccharide Regulation Of Immune Response Response To Molecule Of Bacterial Origin Enzyme Binding Energy Homeostasis Immune Response-regulating Signaling Pathway Cellular Response To Mechanical Stimulus Semicircular Canal Formation JUN Phosphorylation Cellular Response To Lipid ATP Binding Abducens Nerve Formation Optokinetic Behavior Response To Tumor Necrosis Factor Protein Tyrosine Kinase Activity Cellular Response To Stress Regulation Of Immune System Process Regulation Of Synaptic Membrane Adhesion JUN Kinase Activity Smooth Muscle Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Transferase Activity Nucleotide Binding Intracellular Signal Transduction	Intracellular Signal Transduction Nucleus Intracellular Signaling Cassette MAPK Cascade Regulation Of Metabolic Process Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Cytosol Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Protein Kinase Activity Regulation Of Signaling Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of DNA-templated Transcription Developmental Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Communication Chromatin Nucleoplasm Cell Surface Receptor Signaling Pathway Cellular Response To Stress Regulation Of Multicellular Organismal Process Kinase Activity Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of MAPK Cascade Apoptotic Process Cellular Developmental Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Programmed Cell Death Cell Death Response To Growth Factor Negative Regulation Of Macromolecule Metabolic Process