CELF4 and LYST

Number of citations: 0 (PubMedID 11984006)
Data Source: BioGRID (two hybrid)

		CELF4	LYST
Name		CUGBP Elav-like family member 4	lysosomal trafficking regulator
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Postsynapse Ribonucleoprotein Complex	Cytoplasm Microtubule Cytoskeleton
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding BRE Binding	Protein Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Recognition MRNA Processing Germ Cell Development RNA Splicing Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Translation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Excitatory Postsynaptic Potential Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Retina Development In Camera-type Eye	Lymphocyte Mediated Immunity Phagocytosis Immune Response Protein Transport Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus Defense Response To Other Organism
Diseases		None	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Body fat mass ( 28552196 ) Chronotype ( 30696823 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Daytime nap ( 33568662 ) Depression ( 33859377 ) Educational attainment ( 25201988 ) Experiencing mood swings ( 29500382 ) Feeling fed-up ( 29500382 ) Feeling guilty ( 29500382 ) Feeling hurt ( 29500382 ) Feeling miserable ( 29500382 ) Gastroesophageal reflux disease ( 34187846 ) General factor of neuroticism ( 30867560 ) HDL cholesterol levels in HIV infection ( 33109212 ) Household income ( 31844048 ) Household income (MTAG) ( 31844048 ) Mood instability ( 31168069 ) Neurociticism ( 29500382 ) Neuroticism ( 27089181 27067015 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Refractive error ( 32231278 ) Worry too long after an embarrassing experience ( 29500382 )	Basophil percentage of white cells ( 32888494 ) Lymphocyte count ( 32888494 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Systemic lupus erythematosus ( 19838195 26502338 )
Interacting Genes		10 interacting genes: APP LYST PCBP3 PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS2 TIAL1	23 interacting genes: ATN1 CALM1 CELF4 CNTROB CPAP CSNK2B DNAJC14 EFS ESRRA ESS2 HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ ZNF521
Entrez ID		56853	1130
HPRD ID		12534	06060
Ensembl ID		ENSG00000101489	ENSG00000143669
Uniprot IDs		Q9BZC1	Q99698
PDB IDs		2DGP 2DNK	Not available
GO Terms Enriched among Interactors		Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle	Protein Domain Specific Binding Regulation Of Receptor Signaling Pathway Via JAK-STAT Calcium Channel Inhibitor Activity Astral Microtubule Organization Ribonucleoprotein Complex Alternative MRNA Splicing, Via Spliceosome Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Multivesicular Body Organization Multivesicular Body Assembly Centriole Assembly