PSD and GLRA2

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		PSD	GLRA2
Name		pleckstrin and Sec7 domain containing	glycine receptor alpha 2
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Membrane Cleavage Furrow Ruffle Membrane Cell Projection Dendritic Spine Postsynaptic Density, Intracellular Component	Plasma Membrane Membrane Chloride Channel Complex Cell Projection Synapse Postsynaptic Membrane Glycinergic Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phospholipid Binding	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Chloride Channel Activity Glycine Binding Extracellularly Glycine-gated Chloride Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Glycine-gated Chloride Ion Channel Activity Metal Ion Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Signal Transduction Neuron Projection Development Regulation Of ARF Protein Signal Transduction	Monoatomic Ion Transport Chloride Transport Neuropeptide Signaling Pathway Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Cellular Response To Amino Acid Stimulus Cellular Response To Zinc Ion Cellular Response To Ethanol Chloride Transmembrane Transport
Pathways		None	Neurotransmitter receptors and postsynaptic signal transmission Neurotransmitter receptors and postsynaptic signal transmission
Drugs		None	Glycine Lindane Picrotoxin Ethanol Memantine Taurine
GWAS		Apolipoprotein B levels ( 32203549 ) Prostate cancer ( 23535732 ) Refractive error ( 32231278 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Interacting Genes		5 interacting genes: GLRA2 GMFG GNB5 HEXD RAB40C	5 interacting genes: BAG6 DDX24 GDI2 PSD SEC23A
Entrez ID		5662	2742
HPRD ID		09085	02379
Ensembl ID		ENSG00000059915	ENSG00000101958
Uniprot IDs		A5PKW4 Q86YI3	P23416
PDB IDs		Not available	5BKF 5BKG 7KUY 7L31
GO Terms Enriched among Interactors		Glycine-gated Chloride Ion Channel Activity Extracellularly Glycine-gated Chloride Channel Activity Actin Filament Debranching GTPase Activator Complex G-protein Gamma-subunit Binding Light Adaption Dark Adaptation Hexosaminidase Activity Transmitter-gated Monoatomic Ion Channel Activity Beta-N-acetylhexosaminidase Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Postsynaptic Membrane Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Glycinergic Synapse Negative Regulation Of Actin Nucleation Negative Regulation Of Voltage-gated Calcium Channel Activity Cell Tip Glycine Binding Cellular Response To Ethanol Actin Filament Severing Arp2/3 Complex Binding Regulation Of Voltage-gated Calcium Channel Activity GTPase Activity Response To Light Intensity Cul5-RING Ubiquitin Ligase Complex Lipid Droplet Formation Negative Regulation Of Focal Adhesion Assembly Cellular Response To Zinc Ion Parallel Fiber To Purkinje Cell Synapse G Protein-coupled Dopamine Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Transporter Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds	Rab GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Localization To Cilium Mitotic DNA Replication Initiation Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Leading Strand Elongation Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Maintenance Of Unfolded Protein BAT3 Complex Alpha DNA Polymerase:primase Complex COPII-coated Vesicle Budding DNA Replication, Synthesis Of Primer