MASP1 and SERPING1

Number of citations: 0 (PubMedID 10946292)
Data Source: BioGRID (pull down), HPRD (in vitro)

		MASP1	SERPING1
Name		MBL associated serine protease 1	serpin family G member 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol Symbiont Cell Surface	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Proteolysis Complement Activation Complement Activation, Alternative Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Negative Regulation Of Complement Activation Protein Maturation	Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis Blood Circulation Fibrinolysis
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors SARS-CoV-2 activates/modulates innate and adaptive immune responses	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade
Drugs		None	PPL-100 Copper
Diseases		None	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood protein levels ( 30072576 ) Impulsivity (attentional) ( 30718321 ) Type 2 diabetes ( 30130595 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Mean platelet volume ( 32888494 ) Neuroticism ( 29255261 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 ) Schizophrenia ( 25056061 29483656 )
Interacting Genes		16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1	17 interacting genes: BAG6 C1R C1S CFTR ELANE ENO1 F2 HSP90AA1 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2
Entrez ID		5648	710
HPRD ID		02749	06033
Ensembl ID		ENSG00000127241	ENSG00000149131
Uniprot IDs		P48740	E9KL26 P05155
PDB IDs		3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD 7PQO	2OAY 5DU3 5DUQ 7AKV 8W18
GO Terms Enriched among Interactors		Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Opsonization Symbiont Cell Surface Complement Activation Positive Regulation Of Phagocytosis Response To Stress Regulation Of Phagocytosis Classical-complement-pathway C3/C5 Convertase Complex Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Regulation Of Immune Response Positive Regulation Of Endocytosis Ribosomal Protein S6 Kinase Activity Cell Killing Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Opsonization Signal Complex Assembly Activation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Cellular Component Organization Regulation Of Apoptotic Cell Clearance Regulation Of Opsonization Serine-type Endopeptidase Complex Regulation Of Innate Immune Response Protein Kinase Binding Complement Activation, GZMK Pathway TOR Signaling Regulation Of Defense Response Humoral Immune Response Regulation Of Cellular Response To Heat Dynactin Binding Regulation Of Cellular Response To Stress Regulation Of Endocytosis Protein Maturation Blood Microparticle Regulation Of Translation In Response To Stress Regulation Of Complement Activation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Signal Transduction Immune Response-activating Signaling Pathway Protein Serine Kinase Activity Cellular Response To Stress Signal Transduction In Response To DNA Damage Immune Effector Process Protein Metabolic Process Protein Serine/threonine Kinase Activity Response To Bacterium Regulation Of Multicellular Organismal Process	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Response To External Biotic Stimulus Zymogen Activation Activation Of Membrane Attack Complex Immune System Process Killing Of Cells Of Another Organism Opsonization Symbiont Cell Surface Peptidase Activity Extracellular Space Protein Processing Response To Other Organism Response To Stress Cell Killing Cell Surface Positive Regulation Of Leukocyte Tethering Or Rolling Defense Response Positive Regulation Of Immune System Process Negative Regulation Of Fibrinolysis Complement Activation Regulation Of Leukocyte Tethering Or Rolling Protein Maturation Proteolysis Regulation Of Fibrinolysis Fibrinolysis Immune Effector Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Immune Response Activation Of Immune Response Positive Regulation Of Blood Coagulation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Coagulation Defense Response To Symbiont Humoral Immune Response Defense Response To Other Organism Complement Activation, Classical Pathway Blood Microparticle Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Lipopolysaccharide Binding Trans-synaptic Signaling By BDNF Regulation Of Immune System Process Extracellular Region Biological Process Involved In Interaction With Symbiont Hydrolase Activity Complement Component C1 Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Cell Migration Negative Regulation Of Blood Coagulation