MAPK3 and TH

Number of citations: 50 (PubMedID 1347949)
Data Source: BioGRID (enzymatic study), HPRD (in vivo)

		MAPK3	TH
Name		mitogen-activated protein kinase 3	tyrosine hydroxylase
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Caveola Focal Adhesion Cilium Microtubule Cytoskeleton Membrane Pseudopodium Ciliary Basal Body Anchoring Junction Glutamatergic Synapse	Nucleus Cytoplasm Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Cytoplasmic Vesicle Melanosome Membrane Cell Projection Neuron Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphatase Binding Identical Protein Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	Monooxygenase Activity Tyrosine 3-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Autophagosome Assembly MAPK Cascade Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA-templated Transcription Protein Phosphorylation Apoptotic Process DNA Damage Response Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Regulation Of Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Macrophage Chemotaxis Neural Crest Cell Development Schwann Cell Development Phosphorylation Sensory Perception Of Pain Regulation Of Ossification BMP Signaling Pathway Regulation Of Cellular PH Thyroid Gland Development Positive Regulation Of Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Nutrient Levels Positive Regulation Of Telomere Maintenance Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Lipopolysaccharide Regulation Of Stress-activated MAPK Cascade Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation ERBB2-ERBB3 Signaling Pathway TORC1 Signaling Outer Ear Morphogenesis Myelination Glucose Homeostasis Signal Transduction In Response To DNA Damage Response To Exogenous DsRNA Positive Regulation Of Transcription By RNA Polymerase II Insulin-like Growth Factor Receptor Signaling Pathway Thymus Development Modulation Of Chemical Synaptic Transmission Protein Stabilization Negative Regulation Of T Cell Activation Cartilage Development Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization Bergmann Glial Cell Differentiation Face Development Lung Morphogenesis Trachea Formation Cardiac Neural Crest Cell Development Involved In Heart Development Interleukin-34-mediated Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Response To Epidermal Growth Factor Cellular Response To Mechanical Stimulus Cellular Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Negative Regulation Of Cholesterol Efflux Xenophagy Positive Regulation Of Macrophage Proliferation Positive Regulation Of Neuroinflammatory Response Negative Regulation Of TORC1 Signaling Positive Regulation Of Xenophagy Regulation Of Early Endosome To Late Endosome Transport	Response To Hypoxia Synaptic Transmission, Dopaminergic Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Heart Development Visual Perception Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Aromatic Amino Acid Metabolic Process Anatomical Structure Morphogenesis Animal Organ Morphogenesis Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process Eye Photoreceptor Cell Development Eating Behavior Pigmentation Response To Ethanol Embryonic Camera-type Eye Morphogenesis Cognition Hyaloid Vascular Plexus Regression
Pathways		MAPK3 (ERK1) activation RAF-independent MAPK1/3 activation ISG15 antiviral mechanism Signaling by NODAL Spry regulation of FGF signaling Signaling by Activin Frs2-mediated activation ERK/MAPK targets ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth RSK activation Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RNA Polymerase I Promoter Opening Signal attenuation Interferon gamma signaling Advanced glycosylation endproduct receptor signaling Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Regulation of the apoptosome activity Estrogen-dependent nuclear events downstream of ESR-membrane signaling Suppression of apoptosis Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis Nuclear events stimulated by ALK signaling in cancer IFNG signaling activates MAPKs Negative Regulation of CDH1 Gene Transcription NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes Growth hormone receptor signaling Signaling by LTK in cancer Transcriptional and post-translational regulation of MITF-M expression and activity	Catecholamine biosynthesis
Drugs		Sulindac Acetylsalicylic acid Minocycline Arsenic trioxide Colforsin Purvalanol 5-iodotubercidin Seliciclib Cholecystokinin Ulixertinib	Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin
Diseases		None	Primary torsion dystonia (PTD)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Blood protein levels ( 30072576 ) Brain morphology (MOSTest) ( 32665545 ) Childhood body mass index ( 33045005 ) Hodgkin's lymphoma ( 30194254 ) Multiple sclerosis ( 24076602 31604244 ) Pubertal anthropometrics ( 23449627 ) Schizophrenia ( 25056061 28991256 29483656 ) Tonsillectomy ( 27182965 28928442 ) Waist circumference ( 28552196 ) Weight ( 28552196 )	Celiac disease ( 23936387 ) Height ( 31562340 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Prostate cancer ( 19767753 ) Prostate cancer (early onset) ( 24740154 ) Prostate cancer (SNP x SNP interaction) ( 22219177 ) Severe autoimmune type 2 diabetes ( 34737425 ) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926 ) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926 ) Type 2 diabetes ( 25102180 31324766 )
Interacting Genes		194 interacting genes: AKR1C1 AMOT ARRB1 ATP1A1 AURKA BCL2 BCL3 BRAF BTBD10 BTG2 BUB1 C1QBP CALD1 CASP8 CASP9 CAV1 CCDC6 CDC23 CDC25C CDC45 CDH1 CDKN2A CEBPB CPXM1 CREBBP CREM CRP CTNND1 CUEDC2 CYLD DAPK1 DCC DCP1A DEPTOR DLC1 DUSP1 DUSP10 DUSP3 DUSP4 DUSP5 DUSP6 DUSP9 EGFR ELK1 ELK4 EPOR ESR1 ETS1 ETV1 FBXW7 FCGR2B FKBP2 FOS FOXP2 FRS2 GAB1 GAB2 GATA1 GATA4 GJA1 GMFB GRK2 GTF2I HDAC4 HDAC6 HES6 HIF1A HMMR HNF4A HSF1 HSF4 HSPB8 HTRA2 ID2 IER3 INSR IRS1 ITGAV ITGB3 JUN JUND KRT8 KSR2 L3MBTL3 LAMTOR3 LCK LIPE LRPAP1 LRRC4 LYN MAFG MAGEA11 MAGED1 MAP2K1 MAP2K2 MAP2K3 MAP3K14 MAPK14 MAPK8 MAPKAPK2 MAPT MBP MED1 METAP2 MKNK1 MYC MYLK MYOG NAB2 NCKIPSD NGFR NRAS NTRK1 NTRK3 NUP153 NUP58 PAK2 PDCD1 PDE6G PDGFRL PEA15 PFKM PLAT PLCB1 PPARA PPP1CA PPP2CA PRKCD PRKCE PRKCZ PTPN11 PTPN5 PTPN7 PTPRE PTPRR PXN RAB4A RAF1 RALGDS RB1 RCAN1 RET RNF114 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RXRA SCAND1 SCRIB SMAD2 SNCG SORBS3 SOS1 SOX2 SP1 SPIB SRC SREBF1 SREBF2 STAR STAT3 STAT5A STK11 STMN1 STMN2 STUB1 SULT4A1 SYK SYN1 SYNE2 TAL1 TAL2 TCF3 TGIF1 TH TNFSF11 TOP2B TP53 TPD52 TRIM15 TRIM54 TSC2 TTYH3 UBE4B UBTF USP21 VDR VPS52 ZC3HC1 ZNF219 ZNF7	22 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI PIAS2 PRKACA PUF60 RBMY1A1 RPS6KA5 SNCA TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569
Entrez ID		5595	7054
HPRD ID		03479	01865
Ensembl ID		ENSG00000102882	ENSG00000180176
Uniprot IDs		L7RXH5 P27361 Q9BWJ1	P07101 P78428
PDB IDs		2ZOQ 4QTB 6GES	2XSN 4J6S 6ZN2 6ZVP 6ZZU 7A2G 7PIM
GO Terms Enriched among Interactors		Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Developmental Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Regulation Of Apoptotic Process Regulation Of Primary Metabolic Process MAPK Cascade Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Developmental Process Positive Regulation Of DNA-templated Transcription Cellular Response To Oxygen-containing Compound Regulation Of MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Development Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of RNA Biosynthetic Process Protein Kinase Activity Regulation Of RNA Metabolic Process Response To Lipid Negative Regulation Of Multicellular Organismal Process Regulation Of DNA-templated Transcription Regulation Of Cell Population Proliferation	Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Serine Kinase Activity Regulation Of Primary Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity TORC1 Signaling Interleukin-34-mediated Signaling Pathway Kinase Activity Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of Golgi Inheritance Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein Phosphorylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Protein Stability Phosphoserine Residue Binding Protein Domain Specific Binding Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Multicellular Organismal Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of MRNA Processing Focal Adhesion Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Long-term Synaptic Potentiation Nucleus ERK1 And ERK2 Cascade Bergmann Glial Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus