GSDMB and SERPINA1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		GSDMB	SERPINA1
Name		gasdermin B	serpin family A member 1
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Phosphatidylserine Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Cardiolipin Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Programmed Cell Death Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Killing By Host Of Symbiont Cells Transmembrane Transport Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death	Acute-phase Response Blood Coagulation Hemostasis
Pathways		None	Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation
Drugs		None	Zinc 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Mercaptoethanol Recombinant alpha 1-antitrypsin PPL-100 Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		None	Alpha-1-antitrypsin (A1AT) deficiency
GWAS		Adult asthma ( 30787307 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 29273806 28461288 20860503 21804549 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 29273806 34022066 24241537 31036433 27611488 30929738 ) Asthma (time to onset) ( 27130862 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atrial fibrillation ( 30061737 ) Bronchial hyperresponsiveness in asthma ( 27439200 ) Cervical cancer ( 23817570 ) Childhood asthma with severe exacerbations ( 33328473 ) Crohn's disease ( 28067908 ) Dermatomyositis or juvenile dermatomyositis ( 26362759 ) Feeling miserable ( 29500382 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) IgM levels ( 28628107 ) Inflammatory bowel disease ( 23128233 28067908 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Monocyte percentage of white cells ( 27863252 ) Primary biliary cholangitis ( 23000144 20639880 30643196 ) Primary biliary cirrhosis ( 22961000 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Self-reported allergy ( 23817569 ) Serum alkaline phosphatase levels ( 33339817 ) Subcutaneous adipose tissue ( 27918534 ) Systemic lupus erythematosus ( 26502338 ) Systemic sclerosis ( 31672989 28314753 ) Type 1 diabetes ( 30659077 25751624 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 21738480 32888494 )	Age at first sexual intercourse ( 34211149 ) Alanine aminotransferase levels ( 34315874 33339817 ) Alanine transaminase levels ( 28887542 ) Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30679032 30643258 ) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956 28029757 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 34315874 ) Bitter alcoholic beverage consumption ( 31046077 ) Blood protein levels ( 23696881 ) Brain morphology (MOSTest) ( 32665545 ) Breast size ( 27182965 ) C-reactive protein levels ( 33227023 30388399 ) Cirrhosis (alcohol related) ( 32853455 ) Cirrhosis (multi-trait analysis) ( 33310085 ) Coronary artery disease ( 29212778 ) Gallstone disease ( 30504769 ) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273 ) Height ( 29782485 28552196 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Large artery stroke ( 28265093 ) LDL cholesterol ( 30275531 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Manganese levels ( 26025379 ) Metabolite levels ( 22916037 ) Myocardial infarction ( 33532862 ) Platelet count ( 27863252 ) Plateletcrit ( 32888494 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317 ) Post bronchodilator percent predicted FEV1 in smoking ( 30068317 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum alkaline phosphatase levels ( 33339817 31666285 ) Serum alpha-fetoprotein levels ( 31666285 ) Sucrose liking ( 31005972 ) Total cholesterol levels ( 30275531 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		8 interacting genes: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1	30 interacting genes: ADAMTS4 ATP5F1C CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE GLP1R GSDMB HSP90AA1 KLK1 KLK3 KLK5 LAMTOR5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SLC13A1 SMAD4 VKORC1
Entrez ID		55876	5265
HPRD ID		17082	02463
Ensembl ID		ENSG00000073605	ENSG00000197249
Uniprot IDs		Q8TAX9	A0A024R6N5 A0A384MDQ7 E9KL23 P01009
PDB IDs		5TIB 5TJ2 5TJ4 7WJQ 8EFP 8ET1 8ET2 8GTJ 8GTK 8GTN	1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 4PYW 5IO1 5NBU 5NBV 6HX4 6I4V 6I7U 6IAY 6ROD 7AEL 7API 7NPK 7NPL 8API 8P4J 8P4U 8PI2 8QZ5 8R13 8R21 9API
GO Terms Enriched among Interactors		Serine-type Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Proteolysis Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Hydrolase Activity Protein Metabolic Process Extracellular Space Collagen Catabolic Process Extracellular Region Collagen Metabolic Process Digestion Metalloendopeptidase Activity Secretory Granule Catabolic Process Macromolecule Metabolic Process Antibacterial Peptide Biosynthetic Process Response To Other Organism Positive Regulation Of Antibacterial Peptide Production Azurophil Granule Lumen Killing By Host Of Symbiont Cells Biological Process Involved In Interaction With Symbiont Zymogen Activation Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Positive Regulation Of Antimicrobial Humoral Response Response To External Biotic Stimulus Signal Recognition Particle Binding Metallopeptidase Activity Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Response To Stress Negative Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Antimicrobial Humoral Response Neutrophil-mediated Killing Of Bacterium Antimicrobial Humoral Response Defense Response To Bacterium Positive Regulation Of Defense Response To Bacterium Protein Maturation Regulation Of Retrograde Protein Transport, ER To Cytosol Protein Processing Regulation Of Defense Response To Bacterium Defense Response Endopeptidase Activity Defense Response To Gram-negative Bacterium Positive Regulation Of Humoral Immune Response Response To Bacterium Neutrophil Mediated Immunity