TMEM165 and AHSP

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TMEM165	AHSP
Name		transmembrane protein 165	alpha hemoglobin stabilizing protein
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Golgi Apparatus Endosome Membrane Membrane Trans-Golgi Network Membrane Cis-Golgi Network Membrane	Cytoplasm Hemoglobin Complex
	Molecular Function	Manganese Ion Transmembrane Transporter Activity Calcium Ion Transmembrane Transporter Activity Antiporter Activity Metal Ion Transmembrane Transporter Activity	Protein Binding Hemoglobin Binding Unfolded Protein Binding
	Biological Process	Protein N-linked Glycosylation Calcium Ion Transport Manganese Ion Transport Intracellular Calcium Ion Homeostasis Golgi Calcium Ion Homeostasis Golgi Calcium Ion Transport Regulation Of Lysosomal Lumen PH Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport	Protein Folding Hemoglobin Metabolic Process Hemopoiesis Erythrocyte Differentiation Protein Stabilization
Drugs		None	Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
GWAS		A body shape index ( 34021172 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Subcortical volume (MOSTest) ( 32665545 ) Systolic blood pressure ( 30578418 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: AHSP ERRFI1 REL	10 interacting genes: CLVS1 FKBP1A HBA2 POLR2M PSMB1 TMEM165 UBE3A VPS9D1 ZC3H12A ZNF20
Entrez ID		55858	51327
HPRD ID		18216	12052
Ensembl ID		ENSG00000134851	ENSG00000169877
Uniprot IDs		Q9HC07	Q549J4 Q9NZD4
PDB IDs		Not available	1W09 1W0A 1W0B 1XZY 1Y01 1Z8U 3IA3 3OVU
GO Terms Enriched among Interactors		Negative Regulation Of Interferon-beta Production Negative Regulation Of Cytokine Production NF-kappaB Complex Hemoglobin Complex Hemoglobin Metabolic Process Hemoglobin Binding Negative Regulation Of Protein Autophosphorylation Chondrocyte Proliferation Negative Regulation Of Collagen Biosynthetic Process Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Oviduct Epithelium Development Lung Vasculature Development Limb Joint Morphogenesis Uterine Epithelium Development Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Lung Epithelium Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Response To 1-oleoyl-sn-glycerol 3-phosphate Cellular Hyperosmotic Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Response To Platelet-derived Growth Factor Stimulus Uterus Development Regulation Of Protein Tyrosine Kinase Activity Bile Acid Biosynthetic Process Response To Platelet-derived Growth Factor Hyperosmotic Response Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Dexamethasone Stimulus Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of ERBB Signaling Pathway Bile Acid Metabolic Process Response To Progesterone Regulation Of Signaling Receptor Activity Regulation Of Cytokine Production Regulation Of Collagen Biosynthetic Process Negative Regulation Of Interleukin-1 Production Regulation Of Keratinocyte Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Intracellular Signaling Cassette Negative Regulation Of Type I Interferon Production Embryo Implantation	None