PLGRKT and EEF1G

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		PLGRKT	EEF1G
Name		plasminogen receptor with a C-terminal lysine	eukaryotic translation elongation factor 1 gamma
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Translation Elongation Factor Activity Protein Binding Cadherin Binding
	Biological Process	Chemotaxis Inflammatory Response Positive Regulation Of Plasminogen Activation	Translation Translational Elongation Response To Virus
Pathways		None	Eukaryotic Translation Elongation Signaling by ALK fusions and activated point mutants
GWAS		Autoimmune thyroid disease ( 32581359 ) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429 ) Medication use (thyroid preparations) ( 31015401 ) Polycystic ovary syndrome ( 30566500 ) Risky sexual behaviors in alcohol dependence ( 28990359 ) Type 1 diabetes (age at diagnosis) ( 33179336 )	Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 )
Interacting Genes		3 interacting genes: EEF1G SAT1 XRCC6	100 interacting genes: ABCC9 ADAP2 AKT1 ANKRD28 ARF1 ARIH2 C11orf58 C1orf174 CARS1 CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CEBPA CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DLG4 DRD3 DYSF ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EID2B EIF4ENIF1 ENOX1 FAM200C FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS1 HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS1 KLHL18 LARS1 LINC01554 LZTS1 MBD1 MCRIP2 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 OGT PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRF PTPRS RBM6 RECQL5 RGL2 RNF26 RPL4P5 RPS28 SAT1 SFRP2 SKIL SLC22A2 SNAPIN SNRPD2 SUMO2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 USP7 WDR33 YWHAG ZDHHC17 ZNF24
Entrez ID		55848	1937
HPRD ID		12961	11745
Ensembl ID		ENSG00000107020	ENSG00000254772
Uniprot IDs		Q9HBL7	P26641 Q53YD7
PDB IDs		Not available	1PBU 5DQS 5JPO
GO Terms Enriched among Interactors		DNA End Binding Ku70:Ku80 Complex Diamine N-acetyltransferase Activity Spermidine Acetylation Putrescine Catabolic Process Spermidine Binding Cellular Response To X-ray Hyperosmotic Salinity Response Cellular Hyperosmotic Salinity Response Nuclear Telomere Cap Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Cellular Response To Salt Stress DNA-dependent Protein Kinase Complex Double-stranded Telomeric DNA Binding Nonhomologous End Joining Complex Polyamine Catabolic Process Spermidine Metabolic Process Putrescine Metabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Polyamine Biosynthetic Process Translation Elongation Factor Activity Cellular Hyperosmotic Response N-acetyltransferase Activity Polyamine Metabolic Process Response To Salt Stress Telomeric DNA Binding Hyperosmotic Response Response To X-ray Cellular Response To Gamma Radiation ATP-dependent Activity, Acting On DNA Cyclin Binding Biogenic Amine Biosynthetic Process Amine Biosynthetic Process DNA Helicase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Protein-DNA Complex Cellular Response To Osmotic Stress	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Translation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleoplasm Positive Regulation Of Proteasomal Protein Catabolic Process Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Neuron Projection Organization MRNA Cleavage And Polyadenylation Specificity Factor Complex TOR Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Cell Differentiation Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Cell Adhesion Mediated By Integrin Regulation Of TORC1 Signaling Regulation Of TOR Signaling Regulation Of Cellular Component Organization Response To Stress Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Kinase Binding Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Developmental Process Hematopoietic Stem Cell Proliferation Protein Metabolic Process Potassium Channel Activator Activity RNA Metabolic Process Glutamatergic Synapse Negative Regulation Of Proteasomal Protein Catabolic Process PML Body Phosphatidylinositol-3,4-bisphosphate Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process TORC1 Signaling Positive Regulation Of TORC1 Signaling Regulation Of Chromosome Organization Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Protein Modification By Small Protein Conjugation