BRK1 and CYFIP2

Number of citations: 0 (PubMedID 8605018)
Data Source: HPRD (in vitro, in vivo)

		BRK1	CYFIP2
Name		BRICK1 subunit of SCAR/WAVE actin nucleating complex	cytoplasmic FMR1 interacting protein 2
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome	Nucleus Cytoplasm Cytosol Membrane SCAR Complex Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding	RNA 7-methylguanosine Cap Binding Protein Binding Small GTPase Binding
	Biological Process	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Cell Morphogenesis Apoptotic Process Cell Adhesion Axon Guidance Cell Projection Assembly Regulation Of Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Proteolysis Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Dendrite Extension Cell-cell Adhesion Regulation Of Postsynapse Assembly
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
GWAS		Arterial stiffness index ( 31235810 )	Alanine aminotransferase levels ( 33547301 ) Asthma ( 31959851 32296059 34103634 ) Daytime sleep phenotypes ( 27126917 ) FEV1 ( 30804560 ) Gamma glutamyl transferase levels ( 29403010 33339817 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Peak expiratory flow ( 30804560 ) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577 )
Interacting Genes		9 interacting genes: BRAP CYFIP2 MRFAP1 NCK1 NCKAP1 NDEL1 PFDN1 PIK3R3 WASF1	22 interacting genes: ABI1 ABI3 APBB1 BIRC3 BRK1 DNMBP FMR1 FXR1 FXR2 GAS7 MTDH NCK1 NCKAP1 OXTR PLG PRPF40A SMAD4 TCERG1 WASF1 WASF2 YWHAG ZC3H12A
Entrez ID		55845	26999
HPRD ID		12818	07556
Ensembl ID		ENSG00000254999	ENSG00000055163
Uniprot IDs		Q8WUW1	B7Z8N7 E7EVJ5 Q96F07
PDB IDs		3P8C 4N78 7USC 7USD 7USE	Not available
GO Terms Enriched among Interactors		SCAR Complex Regulation Of Supramolecular Fiber Organization Lamellipodium Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Filament Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neuron Projection Extension Dendrite Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Actin Filament-based Process Developmental Cell Growth Regulation Of Actin Filament Polymerization Developmental Growth Involved In Morphogenesis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Rac Protein Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Cell Projection Organization Regulation Of Actin Nucleation Lamellipodium Assembly Regulation Of Cellular Component Size Positive Regulation Of Actin Filament Polymerization Small GTPase-mediated Signal Transduction Cell Projection Morphogenesis Small GTPase Binding Regulation Of Cellular Component Organization Intracellular Signaling Cassette Cell Projection Assembly Cell Migration Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Projection Organization Insulin Receptor Signaling Pathway Developmental Growth Axo-dendritic Transport Positive Regulation Of Protein Polymerization Organelle Transport Along Microtubule Dendritic Transport Of Mitochondrion Zygotic Determination Of Anterior/posterior Axis, Embryo Basal Protein Localization Neurofilament Cytoskeleton Regulation Of Protein-containing Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Positive Regulation Of Cap-independent Translational Initiation Eukaryotic Initiation Factor EIF2 Binding	SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Actin Nucleation Lamellipodium Organization Lamellipodium Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Projection Morphogenesis Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Morphogenesis Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Nucleation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Cell Motility Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Supramolecular Fiber Organization Regulation Of Cell Projection Assembly Regulation Of Actin Filament-based Process Postsynapse Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Biological Quality Regulation Of Actin Filament Organization Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Synapse Regulation Of Cell Projection Organization Translation Regulator Activity Positive Regulation Of Translation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Signaling Adaptor Activity Regulation Of Cytoskeleton Organization Cytoplasmic Ribonucleoprotein Granule Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Organization Signal Transduction Presynapse Positive Regulation Of Lamellipodium Organization Lamellipodium Assembly RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Metabolic Process MRNA 3'-UTR Binding