TBC1D23 and EHD2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TBC1D23	EHD2
Name		TBC1 domain family member 23	EH domain containing 2
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Vesicle WASH Complex	Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Caveola Endosome Membrane Membrane Endocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Nervous System Development Brain Development Vesicle-mediated Transport Neuron Projection Development Retrograde Transport, Endosome To Golgi Animal Organ Development Vesicle Tethering To Golgi Embryonic Brain Development	Endocytosis Cortical Actin Cytoskeleton Organization Endocytic Recycling Cilium Assembly Protein Localization To Plasma Membrane Plasma Membrane Tubulation Positive Regulation Of Myoblast Fusion Positive Regulation Of Endocytic Recycling
Pathways		None	Factors involved in megakaryocyte development and platelet production
GWAS		Axial length ( 24144296 ) Refractive error ( 32231278 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738 )	No GWAS studies recorded
Interacting Genes		14 interacting genes: ATOSB CAGE1 EHD2 EIF3B FOXP1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP4-12 NOPCHAP1 SSBP3 STK11 TIAM1 WDR62	14 interacting genes: AP1M1 AP1M2 AP2M1 BPGM CDC42 DDX56 EHBP1 PICALM PICK1 RBSN SLC2A4 SPATA24 TAGLN2 TBC1D23
Entrez ID		55773	30846
HPRD ID		07727	10434
Ensembl ID		ENSG00000036054	ENSG00000024422
Uniprot IDs		Q9NUY8	Q9NZN4
PDB IDs		6JL7 6JM5 8JJ9 8QQF	Not available
GO Terms Enriched among Interactors		Keratin Filament Intermediate Filament Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Tissue Growth Negative Regulation Of Cell Growth Negative Regulation Of Organ Growth Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Neurogenesis Negative Regulation Of Growth Prechordal Plate Formation Midbrain-hindbrain Boundary Initiation Box C/D Methylation Guide SnoRNP Complex Binding Positive Regulation Of Nervous System Development Regulation Of Heart Growth Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Anterior Head Development Positive Regulation Of Interleukin-21 Production	Cytosol Intracellular Transport Clathrin Adaptor Complex Cellular Localization Establishment Of Localization In Cell Clathrin Adaptor Activity Clathrin-coated Vesicle Vesicle-mediated Transport Extrinsic Component Of Presynaptic Endocytic Zone Membrane Protein Transport Intracellular Protein Localization Clathrin-coated Pit Establishment Of Protein Localization AP-1 Adaptor Complex Intracellular Protein Transport Regulation Of Endocytosis Regulation Of Vesicle Size Trans-Golgi Network Membrane Regulation Of Receptor-mediated Endocytosis Clathrin-coated Endocytic Vesicle Synaptic Vesicle Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Endocytosis Clathrin-dependent Endocytosis Dendritic Spine Organization Vesicle Budding From Membrane Cytoplasmic Vesicle Membrane Endocytosis Clathrin-coated Vesicle Membrane Vesicle Cytoplasmic Vesicle Extracellular Exosome Neuron Projection Organization Postsynapse Organization Regulation Of Vesicle-mediated Transport Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Positive Regulation Of Receptor-mediated Endocytosis Endosomal Transport Import Into Cell Membrane Organization Receptor Internalization GBD Domain Binding Storage Vacuole Endocytic Vesicle Membrane Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Receptor Internalization